Oligomeric dual functional antibacterial polycaprolactone
Oligomeric dual functional antibacterial polycaprolactone
复制标题
DOI：
10.1039/c3py01467c
复制
发表时间：
2014-01-01
影响因子：
4.6
通讯作者：
Agarwal, Seema
中科院分区：
文献类型：
--
作者：
Wang, Hui;Synatschke, Christopher V.;Agarwal, Seema
以己内酯为原料，聚胍为大分子引发剂，通过开环聚合制备了具有抗菌和生物降解双重功能的低聚物。线性聚胍盐酸盐（PHMG）的伯氨基（-NH 2）端基作为己内酯聚合的引发位点，导致联合收割机结合PHMG的抗菌性能和PCL提供的可降解性的嵌段共聚物。用2D NMR和MALDI-ToF-MS证实了材料的嵌段结构。此外，该材料在极性溶剂如甲醇中表现出温度依赖性溶解度（上临界溶解温度）。低聚物显示出高的抗菌活性（减少细菌细胞超过3个数量级），即使在短的孵育时间取决于浓度和PHMG：PCL的比例，同时保持酶的可降解性和生物相容性。
Dual functional antibacterial and biodegradable caprolactone (CL) based oligomers were prepared by ring-opening polymerization of caprolactone using a polyguanidine macroinitiator. Primary amino (-NH2) end-groups of linear poly(hexamethylene guanidine) hydrochloride (PHMG) acted as initiating sites for caprolactone polymerization leading to block copolymers which combine the antibacterial properties of PHMG with degradability provided by PCL. The block structure of the material was confirmed with 2D NMR and MALDI-ToF-MS. Furthermore, the material exhibited temperature dependent solubility (upper critical solution temperature) in polar solvents such as methanol. The oligomers showed high antibacterial activity (reduction of bacterial cells was more than 3 orders of magnitude) even at short incubation times depending on the concentration and PHMG : PCL ratio while maintaining enzymatic degradability and biocompatibility.