Effects of neonatal novelty exposure on sexual behavior, fear, and stress-response in adult rats
Effects of neonatal novelty exposure on sexual behavior, fear, and stress-response in adult rats
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DOI：
10.1002/dev.20181
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发表时间：
2007-04-01
影响因子：
2.2
通讯作者：
Lucion, Aldo Bolten
中科院分区：
文献类型：
--
作者：
Benetti, Fernando;de Araujo, Paulo Andrade;Lucion, Aldo Bolten
生命早期的环境刺激可能会导致永久性的行为和生理变化。本研究评估了将幼鼠暴露在新环境中对成年雄性大鼠的行为(旷场测试和性行为)和催乳素应激反应的影响。每天将一半的幼崽移出窝外，并通过处理3min进行刺激，而另一半则留在巢内，并在产后10天内进行相同的处理。在所有幼崽都被送回巢中后，母体行为在产仔和产仔之间没有差别。成年后，OUT雄鼠在旷场试验中表现出更强的一般和中枢运动能力，性行为减少，对束缚应激的反应中催乳素分泌减弱。仔鼠反复暴露在一个新的环境中是导致长期的行为和内分泌变化的一个原因。幼崽过早地暴露在不熟悉的环境中可以减少恐惧和压力反应，还可以减少性行为。我们认为，没有母亲的气味可能是解释成年后所发现的影响的关键。(C)2007年威利期刊公司。
Environmental stimuli in early life may result in permanent behavioral and physiological changes. Present study evaluated the effects of exposing pups to a novel environment on behaviors (open-field test and sexual behavior) and prolactin stress-responses in adult male rats. Half of a litter was daily removed outside (OUT) from the nest and stimulated by handling for 3 min, while the other half remained inside (IN) the nest and was also handled for the same period during the first 10 days postpartum. Maternal behavior after all the pups were returned to the nest was not different between IN and OUT littermates. In adulthood, OUT males showed increased general and central locomotion activity in the open-field test, reduced sexual behavior and attenuated prolactin secretion in response to restraint stress compared with the IN littermates. The repeated exposition of rat pups to a novel environment is a causal factor for the long-lasting behavioral and endocrine changes. The premature exposition of the pup to unfamiliar environments decreases fear and stress-response, and also reduces sexual behavior We suggest that the absence of the odor of the mother may be crucial to explain the effects detected in adulthood. (c) 2007 Wiley Periodicals, Inc.