Heritability of arterial stiffness in a Brazilian population: Baependi Heart Study
Heritability of arterial stiffness in a Brazilian population: Baependi Heart Study
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DOI：
10.1097/hjh.0000000000001133
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发表时间：
2017-01-01
影响因子：
4.9
通讯作者：
Pereira, Alexandre C.
中科院分区：
文献类型：
--
作者：
Alvim, Rafael O.;Horimoto, Andrea R. V. R.;Pereira, Alexandre C.
背景：动脉硬度增加是心血管疾病风险的重要决定因素。此外，人们已经认识到，动脉硬化具有家族聚集性;然而，没有涉及巴西家庭的研究。因此，本研究的目的是评估的遗传性动脉僵硬度在巴西population.Methods：在这项研究中，1675个合格的个人（包括性别和年龄18-102岁）分布在125个家庭居住在市Baependi，位于巴西东南部的一个城市。颈动脉-股动脉脉搏波速度（PWV）采用无创自动装置（Complior; Artech Medical，Pantin，France）测量。方差分量法，在SOLAR计算机软件包（圣安东尼奥，得克萨斯州，美国）中实现，被应用于估计不同统计模型下研究表型的遗传度。
Background: Increased arterial stiffness is an important determinant of cardiovascular disease risk. In addition, it has been recognized that arterial stiffness has familial aggregation; however, there are no studies involving Brazilian families. Thus, the aim of this study was to evaluate the heritability of arterial stiffness in a Brazilian population.Methods: In this study, 1675 eligible individuals (both sexes and aged 18-102 years) were distributed in 125 families resident in the municipality of Baependi, a city located in the southeast of Brazil. Carotid-femoral pulse wave velocity (PWV) was measured with a noninvasive automatic device (Complior; Artech Medical, Pantin, France). Variance component approaches, implemented in the SOLAR computer package (San Antonio, Texas, USA), were applied to estimate the heritability of the studied phenotype under different statistical models.Results: Heritability estimates for carotid-femoral PWV stratified by age ranging from 11 to 35% (higher in individuals aged