Myelinated afferent fiber types that become spontaneously active and mechanosensitive following nerve transection in the rat
Myelinated afferent fiber types that become spontaneously active and mechanosensitive following nerve transection in the rat
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DOI：
10.1016/s0006-8993(99)01190-7
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发表时间：
1999-04-10
期刊：
影响因子：
2.9
通讯作者：
Devor, M
中科院分区：
文献类型：
--
作者：
Tal, M;Wall, PD;Devor, M
由于轴突切断使感觉感受器末端与传入神经元的剩余部分分离，因此很难知道哪种传入类型在荨麻疹损伤后优先发展出异位放电特征。我们比较了大鼠肌肉和皮肤神经的神经末梢神经瘤中异位放电的发生率。自发性放电在受损的腓肠肌内侧神经(后肢肌肉神经)比主要支配后肢皮肤的隐神经和腓肠神经更常见。另一方面，异位机械敏感性在皮神经神经瘤中更为突出。面神经的神经瘤是一种服务于面部横纹肌的脑神经，没有自发放电，异位机械敏感性极低。我们的结论是，自发性异位放电和异位机械敏感性的发展取决于所涉及的有髓传入纤维的类型(C)1999 Elsevier Science B.V.保留所有权利。
It is difficult to know which afferent types preferentially develop ectopic firing characteristics following nettle injury because axotomy disconnects the sensory receptor ending from the remainder of the afferent neuron. We compared the prevalence of ectopic firing originating in nerve-end neuromas of nerves serving muscle and skin in the rat. Spontaneous firing was much more prevalent in the injured medial gastrocnemius nerve, a hindlimb muscle nerve, than in the saphenous and sural nerves which primarily innervate hindlimb skin. Ectopic mechanosensitivity, on the other hand, was more prominent in neuromas of the cutaneous nerves. In neuromas of the facial nerve, a cranial nerve which serves striated muscles of the face, there was no spontaneous discharge and very little ectopic mechanosensitivity. We conclude that the development of spontaneous ectopic discharge and ectopic mechanosensitivity depends on the type of myelinated afferent fiber involved (C) 1999 Elsevier Science B.V. All rights reserved.