Cancer incidence following treatment for infertility at a clinic in the UK
Cancer incidence following treatment for infertility at a clinic in the UK
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DOI：
10.1093/humrep/17.8.2209
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发表时间：
2002-08-01
影响因子：
6.1
通讯作者：
Tan, SL
中科院分区：
文献类型：
--
作者：
Doyle, P;Maconochie, N;Tan, SL
背景技术背景：人们担心卵巢刺激治疗对不孕症的长期健康影响，特别是对癌症风险的影响。本研究的目的是调查在英国一家大型不孕症诊所就诊的一组妇女的癌症发病率。方法：本研究确定了1975年1月1日至1989年12月31日期间在诊所就诊的英国居民女性。对该队列进行随访，并计算癌症发病率。结果：研究队列由5556名妇女组成，其中75%在诊所接受了卵巢刺激药物治疗。从1990年初至1997年底，共有118例癌症（其中乳腺癌55例，子宫体癌4例，卵巢癌6例）发生在队列中。乳腺癌、子宫体癌和卵巢癌的发病率与基于全国癌症发病率的预期没有显著差异，接受激素治疗以刺激卵巢的妇女和未接受激素治疗的妇女的发病率相似。结论：这些数据并不支持一个假设，即在研究的随访期间，不孕症治疗涉及卵巢刺激与乳腺癌、子宫癌和卵巢癌的增加有关。
BACKGROUND: There is concern about the long-term health impact of ovarian stimulation treatment for infertility, in particular the effect on cancer risk. The aim of this study was to investigate the incidence of cancer in a cohort of women attending a large infertility clinic in the UK. METHODS: Women who were UK residents attending the clinic between January 1, 1975 and December 31, 1989 were identified for the study. The cohort was followed-up and cancer incidence rates calculated. RESULTS: The study cohort was made up of 5556 women of whom 75% had received ovarian stimulation drug treatment at the clinic. A total of 118 cancers (including 55 breast, four corpus uteri and six ovarian) were incident in the cohort from the beginning of 1990 to the end of 1997. The incidence rates of cancer of the breast, corpus uteri and ovary were not significantly different from expectation based on national cancer rates, and were similar for women who had received hormonal treatment to stimulate their ovaries and those who had not. CONCLUSIONS: These data do not support a hypothesis linking infertility treatment involving ovarian stimulation with increased breast, uterine and ovarian cancer over the follow-up period studied.