Emerging structural themes in large RNA molecules.
Emerging structural themes in large RNA molecules.
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DOI：
10.1016/j.sbi.2011.03.003
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发表时间：
2011-06
影响因子：
6.8
通讯作者：
Mondragon, Alfonso
中科院分区：
文献类型：
--
作者：
Reiter, Nicholas J;Chan, Clarence W;Mondragon, Alfonso
广泛的三级相互作用网络产生了独特的、高度组织的结构域结构，表征了大RNA分子的三维结构。大RNA分子由连续同轴螺旋的近平面排列的堆叠层形成，整体形状相对平坦。这些分子的功能核心通过一组不同的三级相互作用基序来稳定，这些基序通常将远距离的保守核苷酸区域聚集在一起。尽管来自不同生物体的同源RNA在结构上可能不同，但它们采用结构保守的功能核心，其中包括预组装的活性和/或底物结合位点。这些发现拓宽了我们对 RNA 折叠和三级结构稳定性的理解，说明了大型、复杂的 RNA 如何组装成独特的结构来执行识别和催化。
Extensive networks of tertiary interactions give rise to unique, highly-organized domain architectures that characterize the three-dimensional structure of large RNA molecules. Formed by stacked layers ofa near-planar arrangement of contiguous coaxial helices, large RNA molecules are relatively flat in overall shape. The functional core of these molecules is stabilized by a diverse set of tertiary interaction motifs that often bring together distant regions of conserved nucleotides. Although homologous RNAs from different organisms can be structurally diverse, they adopt a structurally conserved functional core that includes preassembled active and/or substrate binding sites. These findings broaden our understanding of RNA folding and tertiary structure stabilization, illustrating how large, complex RNAs assemble into unique structures to perform recognition and catalysis.