One-pot synthesis of α-diazo-β-hydroxyesters under phase-transfer catalysis and application to the catalytic asymmetric aldol reaction
One-pot synthesis of α-diazo-β-hydroxyesters under phase-transfer catalysis and application to the catalytic asymmetric aldol reaction
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DOI：
10.1016/j.tetlet.2003.11.083
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发表时间：
2004-01-26
影响因子：
1.8
通讯作者：
Nishida, A
中科院分区：
文献类型：
--
作者：
Arai, S;Hasegawa, K;Nishida, A
以对甲苯磺酰氯为原料，在相转移催化下一锅(三步)合成了α-重氮化-β-羟基酯。还研究了重氮酯与醛之间的不对称羟醛缩合反应，得到了中等到良好的对映选择性。(C)2003爱思唯尔有限公司。保留所有权利。
The one-pot (three steps) synthesis of alpha-diazo-beta-hydroxyesters from tosyl chloride under phase-transfer catalysis is described. The catalytic asymmetric aldol reaction between a diazoester and aldehydes was also investigated and gave moderate to good enantioselectivity. (C) 2003 Elsevier Ltd. All rights reserved.