Association between vitamin D and risk of cardiovascular disease in Chinese rural population
Association between vitamin D and risk of cardiovascular disease in Chinese rural population
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维生素D与中国农村人口心血管疾病风险的关系
DOI：
10.1371/journal.pone.0217311
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发表时间：
2019-05
期刊：
影响因子：
3.7
通讯作者：
李文杰
中科院分区：
文献类型：
--
作者：
王腾;孙华磊;葛惠娜;刘欣欣;于菲;韩涵;王俊;李文杰
先前的研究表明维生素D与心血管疾病（CVD）有关，然而，维生素D水平与心血管疾病风险之间的关系仍不明确。本研究的目的是评估血清浓度的关系（最后一个单词“concentrati”不完整，可能影响准确翻译）
Previous studies have suggested that vitamin D is associated with cardiovascular disease (CVD), however, the relationship between vitamin D levels and CVD risk is still unclear. The purpose of this study was to assess the relationship of serum concentration of 25-hydroxyvitamin D (25(OH)D) with CVD in rural residents of Henan province of China. Basic information and medical history were gathered through face-to-face surveys from July 2013 to August 2015, and biochemical indicators were gathered in a laboratory setting. Logistic and restricted cubic splines regression analyses were used to estimate odd ratios (ORs) and 95% confidence intervals (95%CI) of CVD. A total of 1078 participants were included, the mean serum 25(OH)D concentration was determined to be 25 ± 18 ng/ml, with 54.45% of the participants presenting vitamin D deficiency [25(OH)D < 20 ng/mL]. Moreover, the prevalence of CVD was 59.28% in the vitamin D deficient group, which was higher than in the insufficient (48.55%) and sufficient groups (52.78%). After adjusting for potential confounders, compared with the deficient group, the ORs (95%CI) of CVDs were 0.68 (0.50, 0.91) in the insufficient group and 0.81 (0.56, 1.16) in the sufficient group. A nonlinear (U-shaped) association was observed between the risk of CVD and 25(OH)D concentration. Further research suggested that the risk of CVD was higher in males than in females. In conclusion, a U-shape association between serum levels of 25(OH)D and the risk of CVD was identified in our study, suggesting a nonlinear relationship between vitamin D with the prevalence of CVD.
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影响因子：
2.8
作者：
Liu, Longjian;Chen, Ming;Eisen, Howard J.
通讯作者：
Eisen, Howard J.
影响因子：
--
作者：
T. Oppé
通讯作者：
T. Oppé
DOI：
10.1016/b978-0-12-802965-7.00007-1
发表时间：
2017-01-01
期刊：
VITAMINS: FUNDAMENTAL ASPECTS IN NUTRITION AND HEALTH, 5TH EDITION
影响因子：
--
作者：
Combs, Gerald F., Jr.;McClung, James P.
通讯作者：
McClung, James P.
影响因子：
1.8
作者：
M. Holick
通讯作者：
M. Holick
影响因子：
5.8
作者：
Holick, Michael F.;Binkley, Neil C.;Weaver, Connie M.
通讯作者：
Weaver, Connie M.