Selection in utero against male twins in the United States early in the COVID-19 pandemic.
Selection in utero against male twins in the United States early in the COVID-19 pandemic.
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在 COVID-19 大流行初期，美国在子宫内选择男性双胞胎。
DOI：
10.1002/ajhb.23830
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Catalano,Ralph
中科院分区：
文献类型：
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作者：
Bruckner,TimA;Bustos,Brenda;Margerison,Claire;Gemmill,Alison;Casey,Joan;Catalano,Ralph
目的对宫内选择试验的文献报道有所贡献。生殖抑制理论预测，自然选择将保留一些机制，这些机制被统称为子宫内的选择，这些机制会自动流产那些在主流环境中不太可能像婴儿一样茁壮成长的胎儿。对这一预测的检验包括，有报道称，在压力时期，女性生下的男性双胞胎比预期的要少，而男性双胞胎历来是最脆弱的婴儿之一。2020年春季美国爆发的COVID - 19大流行明显给人口带来了压力。我们检验了这样一个假设，即在美国大流行开始时，妊娠期的受孕队列产生的活双胞胎男婴少于预期。方法：我们从美国国家卫生统计中心的出生证明记录中检索美国所有活产婴儿的未识别数据。我们应用Box - Jenkins时间序列方法对2013年8月至2019年12月期间77个月度受孕队列的双胞胎第二性比进行计算，以检测大流行开始时处于妊娠期的外围队列。结果2019年7月、9月和10月三个受孕队列的双胞胎第二性别比均低于期望值，均p<。05)在子宫内接触到大流行的开始。结论sour的结果与先前的发现一致，与子宫内的选择一致。子宫内的选择在塑造活产队列特征方面的作用，特别是在COVID - 19大流行期间，值得进一步研究。
ObjectivesWe aim to contribute to the literature reporting tests of selection in utero. The theory of reproductive suppression predicts that natural selection would conserve mechanisms, referred to collectively as selection in utero, that spontaneously abort fetuses unlikely to thrive as infants in the prevailing environment. Tests of this prediction include reports that women give birth to fewer than expected male twins, historically among the frailest of infants, during stressful times. The onset of the COVID‐19 pandemic in the United States in Spring 2020 demonstrably stressed the population. We test the hypothesis that conception cohorts in gestation at the onset of the pandemic in the United States yielded fewer than expected live male twin births.MethodsWe retrieved deidentified data on the universe of live births in the United States from the National Center for Health Statistics birth certificate records. We applied Box‐Jenkins time‐series methods to the twin secondary sex ratio computed for 77 monthly conception cohorts spanning August 2013 to December 2019 to detect outlying cohorts in gestation at the onset of the pandemic.ResultsThe twin secondary sex ratio fell below expected values in three conception cohorts (i.e., July, September, and October 2019, allp< .05) exposed in utero to the onset of the pandemic.ConclusionsOur results add to prior findings consistent with selection in utero. The role of selection in utero in shaping the characteristics of live births cohorts, especially during the COVID‐19 pandemic, warrants further scrutiny.