An Allometric Relationship between the Genome Length and Virion Volume of Viruses
An Allometric Relationship between the Genome Length and Virion Volume of Viruses
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DOI：
10.1128/jvi.00362-14
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发表时间：
2014-06-01
影响因子：
5.4
通讯作者：
Holmes, Edward C.
中科院分区：
文献类型：
--
作者：
Cui, Jie;Schlub, Timothy E.;Holmes, Edward C.
病毒粒子的大小至少有4个数量级的差异，但造成这种巨大多样性的进化力量尚不清楚。我们记录了一个显着的异速生长关系，指数约为1.5，基因组长度和病毒体体积的病毒，并发现这种关系是不是由于几何约束。值得注意的是，无论基因组核酸、基因组结构或病毒体结构的类型如何，这种异速生长关系都成立，因此代表了强大的比例定律。相反，在单个基因的尺度上没有观察到这种关系。类似地，在调整基因组长度后，没有观察到病毒体体积和蛋白质数量之间的关联，排除了蛋白质数量作为基因组和病毒体大小之间关系的解释。这种基本的异速生长关系不仅揭示了对病毒进化的限制，因为病毒体大小的增加而不一定是结构的增加与基因组大小的伴随增加相关，而且还意味着自然界中的病毒体大小可以仅从基因组序列数据广泛预测。
Virions vary in size by at least 4 orders of magnitude, yet the evolutionary forces responsible for this enormous diversity are unknown. We document a significant allometric relationship, with an exponent of approximately 1.5, between the genome length and virion volume of viruses and find that this relationship is not due to geometric constraints. Notably, this allometric relationship holds regardless of genomic nucleic acid, genome structure, or type of virion architecture and therefore represents a powerful scaling law. In contrast, no such relationship is observed at the scale of individual genes. Similarly, after adjusting for genome length, no association is observed between virion volume and the number of proteins, ruling out protein number as the explanation for the relationship between genome and virion sizes. Such a fundamental allometric relationship not only sheds light on the constraints to virus evolution, in that increases in virion size but not necessarily structure are associated with concomitant increases in genome size, but also implies that virion sizes in nature can be broadly predicted from genome sequence data alone.