17-nor-Cephalotane-Type Diterpenoids from Cephalotaxus fortunei
17-nor-Cephalotane-Type Diterpenoids from Cephalotaxus fortunei
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三尖杉中的 17-正三尖杉烷型二萜类化合物
DOI：
10.1021/acs.jnatprod.9b00059
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发表时间：
2019-06-01
影响因子：
5.1
通讯作者：
Yue, Jian-Min
中科院分区：
文献类型：
--
作者：
Ge, Zhan-Peng;Liu, Hong-Chun;Yue, Jian-Min
从高山头杉（Cephalotaxus fortunei varo . alpine）种子中分离到17个新的17-非头孢烷型二萜类化合物fortalpinoids A-Q（1-17）。化合物12是第一个具有8-氧杂环[3.2.1]辛-2-烯片段的17-去头孢烷型二萜。首次确定了fortunolide A（18）的绝对构型，并通过x射线晶体学数据分析将其结构修正为14-epi-cephafortoid A（24）。部分化合物对A549和HL-60细胞具有明显的细胞毒性，并讨论了该类化合物的构效关系。
Seventeen new 17-nor-cephalotane-type diterpenoids, fortalpinoids A-Q (1-17), were isolated from the seeds of Cephalotaxus fortunei var. alpine. Compound 12 represents the first 17-nor-cephalotane-type diterpenoid featuring an 8-oxabicyclo[3.2.1]oct-2-ene moiety. The absolute configuration of fortunolide A (18) was determined for the first time, and the structure of cephinoid Qwas revised to 14-epi-cephafortoid A (24) by X-ray crystallographic data analysis. Some of the compounds showed significant cytotoxicity against A549 and HL-60 cells, and the structure activity relationship of this compound class is discussed.