Incidence and clinical features of extramedullary multiple myeloma in patients who underwent stem cell transplantation.
Incidence and clinical features of extramedullary multiple myeloma in patients who underwent stem cell transplantation.
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DOI：
10.1111/bjh.13383
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发表时间：
2015-06
影响因子：
6.5
通讯作者：
Ghobrial IM
中科院分区：
文献类型：
--
作者：
Weinstock M;Aljawai Y;Morgan EA;Laubach J;Gannon M;Roccaro AM;Varga C;Mitsiades CS;Paba-Prada C;Schlossman R;Munshi N;Anderson KC;Richardson PP;Weller E;Ghobrial IM
Extramedullary disease (EMD), defined as an infiltrate of clonal plasma cells at an anatomic site distant from the bone marrow, is an uncommon manifestation of multiple myeloma. Six hundred and sixty-three consecutive patients with multiple myeloma who underwent stem cell transplantation between January 2005 and December 2011 were assessed for the presence of EMD. A cohort of 55 patients with biopsy-proven EMD was identified, comprising 8.3% of the total study population. EMD was present at the time of diagnosis in 14.5% of cases and at the time of relapse in 76% of patients. The most common EMD presentations at relapse were liver involvement and pleural effusions. EMD specimens had high expression of CD44 (92%) and moderate expression of CXCR4. The median overall survival from time of myeloma diagnosis was 4.1 years (95% confidence interval: 3.1, 5.1) and the median overall survival from time of EMD diagnosis was 1.3 years (95% confidence interval: 0.8, 2.3). This report demonstrates that the incidence of EMD has not increased with the introduction of novel agents and stem cell transplantation. The most common EMD presentations in the relapsed setting were liver and pleural fluid. The presence of CD44 and CXCR4 expression may represent new markers of EMD that warrant further investigation.
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影响因子：
39.2
作者：
BARLOGIE, B;SMALLWOOD, L;ALEXANIAN, R
通讯作者：
ALEXANIAN, R
DOI：
10.3324/haematol.2012.065698
发表时间：
2012-11-01
期刊：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
影响因子：
--
作者：
Usmani, Saad Z.;Heuck, Christoph;Barlogie, Bart
通讯作者：
Barlogie, Bart
影响因子：
20.3
作者：
Bartel, Twyla B.;Haessler, Jeff;Barlogie, Bart
通讯作者：
Barlogie, Bart
影响因子：
45.3
作者：
BLADE, J;LUST, JA;KYLE, RA
通讯作者：
KYLE, RA
影响因子：
50.5
作者：
Varettoni, M.;Corso, A.;Lazzarino, M.
通讯作者：
Lazzarino, M.