Hepatitis B virus X protein-mediated non-coding RNA aberrations in the development of human hepatocellular carcinoma.
Hepatitis B virus X protein-mediated non-coding RNA aberrations in the development of human hepatocellular carcinoma.
复制标题
乙型肝炎病毒X蛋白介导的非编码RNA异常在人肝细胞癌发生中的作用
DOI：
10.1038/emm.2016.177
复制
发表时间：
2017-02-10
影响因子：
12.8
通讯作者：
Wang R
中科院分区：
文献类型：
--
作者：
Zhang B;Han S;Feng B;Chu X;Chen L;Wang R
Hepatitis B virus (HBV) has an important role in the development of human hepatocellular carcinoma (HCC). Accumulated evidence has shown that HBV-encoded X protein (HBx) can induce both genetic alterations in tumor suppressor genes and oncogenes, as well as epigenetic aberrations in HCC pathogens. Non-coding RNAs (ncRNAs) mainly include microRNAs and long non-coding RNAs (lncRNAs). Although ncRNAs cannot code proteins, growing evidence has shown that they have various important biological functions in cell proliferation, cell cycle control, anti-apoptosis, epithelial–mesenchymal transition, tumor invasion and metastasis. This review summarizes the current knowledge regarding the mechanisms and emerging roles of ncRNAs in the pathogenesis of HBV-related HCC. Accumulated data have shown that ncRNAs regulated by HBx have a crucial role in HBV-associated hepatocarcinogenesis. The findings of these studies will contribute to more clinical applications of HBV-related ncRNAs as potential diagnostic markers or as molecular therapeutic targets to prevent and treat HBV-related HCC.
