VDAC: The channel at the interface between mitochondria and the cytosol
VDAC: The channel at the interface between mitochondria and the cytosol
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DOI：
10.1023/b:mcbi.0000009862.17396.8d
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发表时间：
2004-01-01
影响因子：
4.3
通讯作者：
Colombini, M
中科院分区：
文献类型：
--
作者：
Colombini, M
线粒体外膜不仅是一个屏障，而且是调节线粒体功能的场所。蛋白质的VDAC家族是代谢物通量通过外膜的主要途径。这些可以以多种方式调节，并且这些调节输入的整合允许线粒体代谢被调节以改变细胞条件。这包括阴离子代谢物通量的完全阻断，导致外膜对小蛋白的透化，随后是凋亡性细胞死亡。
The mitochondrial outer membrane is not just a barrier but a site of regulation of mitochondrial function. The VDAC family of proteins are the major pathways for metabolite flux through the outer membrane. These can be regulated in a variety of ways and the integration of these regulatory inputs allows mitochondrial metabolism to be adjusted to changing cellular conditions. This includes total blockage of the flux of anionic metabolites leading to permeabilization of the outer membrane to small proteins followed by apoptotic cell death.