Hippocampal network oscillations as mediators of behavioural metaplasticity: Insights from emotional learning
Hippocampal network oscillations as mediators of behavioural metaplasticity: Insights from emotional learning
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DOI：
10.1016/j.nlm.2018.02.022
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发表时间：
2018-10-01
影响因子：
2.7
通讯作者：
Stork, Oliver
中科院分区：
文献类型：
--
作者：
Caliskan, Guersel;Stork, Oliver
在连接海马、杏仁核和内侧前额叶皮层的神经元回路中，网络活动模式的经验依赖性变化中，行为后可塑性是明显的。这些边缘区域是全脑神经网络的关键结构，可以将情绪上突出的事件转化为持久而生动的记忆。该网络中的通信大体上取决于行为状态依赖的节律网络活动模式，这些模式通常通过海马体生成和/或中继。事实上，特定的海马网络振荡与情感记忆的获得、巩固和提取以及重新巩固和消退有关。同时，在记忆形成过程中，对这些网络活动有贡献的海马回路受到赫布和非赫布形式的可塑性的影响。此外，它已成为明显的是，适应性变化的视丘依赖性网络活动模式提供了一个重要的手段，调整突触可塑性。在这里，我们总结了我们目前的知识，这些过程中的海马体与杏仁核和内侧前额叶皮层的相互作用，介导的形成和持久的情绪记忆。
Behavioural metaplasticity is evident in experience dependent changes of network activity patterns in neuronal circuits that connect the hippocampus, amygdala and medial prefrontal cortex. These limbic regions are key structures of a brain-wide neural network that translates emotionally salient events into persistent and vivid memories. Communication in this network by-and-large depends on behavioural state-dependent rhythmic network activity patterns that are typically generated and/or relayed via the hippocampus. In fact, specific hippocampal network oscillations have been implicated to the acquisition, consolidation and retrieval, as well as the reconsolidation and extinction of emotional memories. The hippocampal circuits that contribute to these network activities, at the same time, are subject to both Hebbian and non-Hebbian forms of plasticity during memory formation. Further, it has become evident that adaptive changes in the hippocampus-dependent network activity patterns provide an important means of adjusting synaptic plasticity. We here summarise our current knowledge on how these processes in the hippocampus in interaction with amygdala and medial prefrontal cortex mediate the formation and persistence of emotional memories.