Programmed cell death mediated by ced-3 and ced-4 protects Caenorhabditis elegans from Salmonella typhimurium-mediated killing
Programmed cell death mediated by ced-3 and ced-4 protects Caenorhabditis elegans from Salmonella typhimurium-mediated killing
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DOI：
10.1073/pnas.041613098
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发表时间：
2001-02-27
影响因子：
11.1
通讯作者：
Ausubel, FM
中科院分区：
文献类型：
--
作者：
Aballay, A;Ausubel, FM
哺乳动物的程序性细胞死亡(PCD)与多种疾病状态有关，包括癌症、自身免疫性疾病和神经退行性疾病。在秀丽线虫中，PCD是发育的正常组成部分。我们发现，鼠伤寒沙门氏菌在线虫肠道的定植导致线虫性腺中细胞死亡水平的增加。在发育调节细胞死亡被阻断的线虫Ced-3和Ced-4突变体中，没有观察到鼠伤寒沙门氏菌介导的生殖系细胞死亡，并且Ced-3和Ced-4：突变体对鼠伤寒沙门氏菌介导的杀伤超敏。这些结果提示PCD可能参与线虫对病原体攻击的防御反应。
Programmed cell death (PCD) in mammals has been implicated in several disease states including cancer, autoimmune disease, and neurodegenerative disease. In Caenorhabditis elegans, PCD is a normal component of development. We find that Salmonella typhimurium colonization of the C. elegans intestine leads to an increased level of cell death in the worm gonad. S. typhimurium-mediated germ-line cell death is not observed in C. elegans ced-3 and ced-4 mutants in which developmentally regulated cell death is blocked, and ced-3 and ced-4: mutants are hypersensitive to S. typhimurium-mediated killing. These results suggest that PCD may be involved in the C. elegans defense response to pathogen attack.