[Sleep-wake cycle mechanisms].
[Sleep-wake cycle mechanisms].
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DOI：
10.1590/s1516-44462005000500007
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发表时间：
2005-05
影响因子：
--
通讯作者：
F. Alóe;A. Azevedo;R. Hasan
中科院分区：
文献类型：
--
作者：
F. Alóe;A. Azevedo;R. Hasan
神经化学上不同的系统相互作用调节睡眠和觉醒。觉醒是由胺能、乙酰胆碱能脑干和下丘脑系统促进的。这些唤醒系统中的每一个都支持觉醒，并且需要协调的活动来保持警觉和EEG激活。脑桥和视前区的神经元控制快速眼动和非快速眼动睡眠。这些清醒和睡眠调节系统之间的相互抑制产生了行为状态。对这些系统的最新了解应该使临床医生和研究人员能够更好地了解药物，病变和神经系统疾病对睡眠和觉醒的影响。
Neurochemically distinct systems interact regulating sleep and wakefulness. Wakefulness is promoted by aminergic, acetylcholinergic brainstem and hypothalamic systems. Each of these arousal systems supports wakefulness and coordinated activity is required for alertness and EEG activation. Neurons in the pons and preoptic area control rapid eye movement and non-rapid eye movement sleep. Mutual inhibition between these wake- and sleep-regulating systems generate behavioral states. An up-to-date understanding of these systems should allow clinicians and researchers to better understand the effects of drugs, lesions, and neurologic disease on sleep and wakefulness.