Intake of very long-chain n-3 fatty acids from fish and incidence of atrial fibrillation. The Rotterdam Study
Intake of very long-chain n-3 fatty acids from fish and incidence of atrial fibrillation. The Rotterdam Study
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DOI：
10.1016/j.ahj.2005.07.029
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发表时间：
2006-04-01
影响因子：
4.8
通讯作者：
Witteman, JCM
中科院分区：
文献类型：
--
作者：
Brouwer, IA;Heeringa, J;Witteman, JCM
研究背景心房颤动是最常见的持续性心律失常。通过增加血栓栓塞性卒中的风险，它是发病率和死亡率的主要原因。实验和观察证据表明，n-3多不饱和脂肪酸可能具有抗肿瘤作用。本研究的目的是检查是否高摄入量的鱼类和其非常长链的n-3脂肪酸二十碳五烯酸（EPA）加二十二碳六烯酸（DHA）与事件房颤的风险。方法我们使用的数据从鹿特丹研究，前瞻性队列研究。基线时，可获得5 184例无房颤受试者的饮食摄入数据。采用半定量食物频率问卷评估饮食摄入，并在随访期间持续监测房颤的发生率。考克斯比例风险模型（调整的生活方式和疾病因素）被用来检查EPA和DHA和鱼类的摄入量与房颤的关联。结果经过平均6.4（+/- 1.6）年的随访，312名受试者发生房颤。与第一种纺织品相比，第三种纺织品中EPA和DHA的摄入量与房颤风险无关（相对风险1.18，95% CI 0.88-1.57）。此外，与不摄入鱼类相比，摄入> 20 g/d鱼类与房颤的发生无相关性（相对危险度1.17，95%CI 0.87-1.57）。结论在本研究中，EPA和DHA的摄入量以及鱼类的摄入量与房颤的发生无关。这一发现并不支持n-3脂肪酸具有普遍的抗肿瘤作用。
Background Atrial fibrillation is the most common sustained cardiac arrhythmia. It is a major cause of morbidity and mortality through an increased risk of thromboembolic stroke. Experimental as well as observational evidence suggests that n-3 polyunsaturated fatty acids may have antiarrhythmic effects. The objective of this study was to examine whether high intakes of fish and its very long-chain n-3 fatty acids eicosapentoenoic acid (EPA) plus docosahexaenoic acid (DHA) are associated with risk of incident atrial fibrillation.Methods We used data from the Rotterdam Study, a prospective cohort study. At baseline, dietary intake data were available for 5 184 subjects free from atrial fibrillation. Dietary intake was assessed using a semiquantitative food-frequency questionnaire, and incidence of atrial fibrillation was continuously monitored during follow-up. Cox proportional hazards model (adjusted for lifestyle and disease factors) was used to examine the associations between intakes of EPA plus DHA and of fish with atrial fibrillation.Results After a mean follow-up of 6.4 (+/- 1.6) years, 312 subjects developed atrial fibrillation. Intake of EPA and DHA in the third textile compared with first was not associated with risk of atrial fibrillation (relative risk 1.18, 95% Cl 0.88-1.57). Furthermore, no association was observed with intake of > 20 g/d fish compared with no fish intake (relative risk 1.17, 95% Cl 0.87-1.57).Conclusions In this study, intakes of EPA and DHA and the consumption of fish were not associated with the onset of atrial fibrillation. This finding does not support that n-3 fatty acids have a general antiarrhythmic effect.