Human resistance to Schistosoma mansoni is associated with IgG reactivity to a 37-kDa larval surface antigen.
Human resistance to Schistosoma mansoni is associated with IgG reactivity to a 37-kDa larval surface antigen.
复制标题
人类对曼氏血吸虫的抵抗力与 IgG 对 37 kDa 幼虫表面抗原的反应性有关。
DOI：
10.4049/jimmunol.140.8.2727
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发表时间：
1988
影响因子：
4.4
通讯作者：
J. C. Bina
中科院分区：
文献类型：
--
作者：
A. Dessein;M. Begley;C. Demeure;D. Caillol;J. Fueri;M. G. D. Reis;Z. Andrade;A. Prata;J. C. Bina
这项工作的目的是确定人类对曼氏血吸虫的抗性是否与某些幼虫表面抗原的抗体反应性增加有关。为此，选择高流行区的年轻居民，他们的低或高的易感性寄生虫治疗后再感染，并在治疗前后的不同时间测定他们的血清对个别幼虫表面抗原的反应性。数据显示，6种Ag：202、165、90至92、85、72和37 kDa是抗性受试者血清中IgG幼虫的主要靶标。比较研究，免疫印迹和ELISA纯化的Ag，从高和低敏感性受试者的血清表明，对37 kDa的抗原的IgG反应性可能与耐药性。这项工作和正在进行的小鼠疫苗接种试验表明，37 kDa的抗原可能具有接种潜力。
The aim of this work was to determine whether human resistance to Schistosoma mansoni was associated with increased antibody reactivity to certain larval surface Ag. To this end, young residents of a hyperendemic area were selected for their low or high susceptibility to reinfection after parasitologic cure, and the reactivity of their sera to individual larval surface Ag was determined at different times before and after treatment. The data showed that six Ag: 202, 165, 90 to 92, 85, 72, and 37 kDa are the principal targets on the larva of IgG in the sera of resistant subjects. The comparative study, by immunoblotting and ELISA on purified Ag, of the sera from high and low susceptibility subjects indicates that IgG reactivity toward the 37-kDa Ag may be associated with resistance. This work and ongoing vaccination trials carried out in mice suggest that the 37-kDa Ag may have vaccinating potentials.