Distinct temporal difference error signals in dopamine axons in three regions of the striatum in a decision-making task.
Distinct temporal difference error signals in dopamine axons in three regions of the striatum in a decision-making task.
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DOI：
10.7554/elife.62390
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发表时间：
2020-12-21
期刊：
影响因子：
7.7
通讯作者：
Watabe-Uchida M
中科院分区：
文献类型：
--
作者：
Tsutsui-Kimura I;Matsumoto H;Akiti K;Yamada MM;Uchida N;Watabe-Uchida M
纹状体的不同区域调节不同类型的行为。然而，多巴胺信号在纹状体区域之间有何不同以及多巴胺如何调节不同的行为仍不清楚。在这里，我们比较了小鼠执行感知和基于价值的决策任务时腹侧、背内侧和背外侧纹状体的多巴胺轴突活性。令人惊讶的是，所有三个区域的多巴胺轴突活性相似。乍一看，该活动在任务的不同阶段混合了不同的变量，例如与刺激相关的价值观、信心和奖励反馈。然而，我们的模型表明，这些调制可以通过预期奖励的每时每刻的变化来解释，即时间差异误差。区域之间的主要差异是奖励反应的总体活动水平：背外侧纹状体的奖励反应发生正向转移，缺乏对负面预测错误的抑制反应。多巴胺信号的差异对这些区域中多巴胺控制的行为特性施加了特定的限制。
Different regions of the striatum regulate different types of behavior. However, how dopamine signals differ across striatal regions and how dopamine regulates different behaviors remain unclear. Here, we compared dopamine axon activity in the ventral, dorsomedial, and dorsolateral striatum, while mice performed a perceptual and value-based decision task. Surprisingly, dopamine axon activity was similar across all three areas. At a glance, the activity multiplexed different variables such as stimulus-associated values, confidence, and reward feedback at different phases of the task. Our modeling demonstrates, however, that these modulations can be inclusively explained by moment-by-moment changes in the expected reward, that is the temporal difference error. A major difference between areas was the overall activity level of reward responses: reward responses in dorsolateral striatum were positively shifted, lacking inhibitory responses to negative prediction errors. The differences in dopamine signals put specific constraints on the properties of behaviors controlled by dopamine in these regions.