Control of adenovirus packaging
Control of adenovirus packaging
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DOI：
10.1002/jcb.20523
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发表时间：
2005-09-01
影响因子：
4
通讯作者：
Hearing, P
中科院分区：
文献类型：
--
作者：
Ostapchuk, P;Hearing, P
腺病毒的研究成果有助于我们对细胞分子生物学的基本认识。虽然关于Ad基因表达、病毒复制和对受感染宿主的影响已经有了大量的知识，但腺病毒颗粒组装过程的分子细节在很大程度上是未知的。在这篇文章中，我们想为腺病毒的包装和组装提出一个理论模型，并提出了研究的概述，这些研究有助于我们目前的理解。特别是，我们将总结病毒DNA包装成病毒颗粒过程的分子细节，并强调包装和组装过程中需要进一步研究的事件。
The results of studies of Adenovirus have contributed to our basic understanding of the molecular biology of the cell. While a great body of knowledge has been developed concerning Ad gene expression, viral replication, and effects on the infected host, the molecular details of the assembly process of Adenovirus particles are largely unknown. In this article, we would like to propose a theoretical model for the packaging and assembly of Adenovirus and present an overview of the studies that have contributed to our present understanding. In particular, we will summarize the molecular details of the process for packaging of viral DNA into virus particles and highlight the events in packaging and assembly that require further study.