Relapses in multiple sclerosis are associated with increased CD8+ T-cell mediated cytotoxicity in CSF
Relapses in multiple sclerosis are associated with increased CD8+ T-cell mediated cytotoxicity in CSF
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DOI：
10.1016/j.jneuroim.2008.03.001
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发表时间：
2008-05-30
影响因子：
3.3
通讯作者：
Olsson, Bob
中科院分区：
文献类型：
--
作者：
Malmestrom, Clas;Lycke, Jan;Olsson, Bob
MS被认为是由CD 4（+）T辅助细胞介导的。为了研究CD 8（+）细胞毒性T细胞在MS中的重要性，我们通过DNA微阵列分析了MS患者和对照组的外周血T细胞，以及血浆和CSF中颗粒酶的水平。RRMS患者外周血T细胞的细胞毒性基因表达降低，而血浆颗粒酶水平不变。然而，与对照组和缓解组相比，复发时RRMS患者CSF中的颗粒酶水平升高。因此，CD 8 + T细胞介导的细胞毒性仅限于RRMS患者的CSF/CNS区室，并可能参与临床复发的免疫发病机制。(C)2008 Elsevier B. V.保留所有权利。
MS is thought to be mediated by CD4(+) T-helper cells. To investigate the importance of CD8(+) cytotoxic T-cells in MS we analyzed peripheral blood T-cells by DNA microarray, and plasma and CSF levels of granzymes from MS patients and controls. Cytotoxic gene expression was decreased in peripheral T-cells from RRMS patients whereas plasma levels of granzymes were unchanged. However, granzyme levels were elevated in the, CSF of RRMS patients at relapse compared with controls and remission. Thus, CD8+ T-cell-mediated cytotoxicity is confined to the CSF/CNS compartment in RRMS patients and may be involved in the immunopathogenesis of clinical relapses. (C) 2008 Elsevier B.V. All rights reserved.