Cardiovascular Disease in Women: Does Menopause Matter?
Cardiovascular Disease in Women: Does Menopause Matter?
复制标题
DOI：
10.1016/j.coemr.2022.100419
复制
发表时间：
2022-12-01
影响因子：
--
通讯作者：
Nasr, Alexis
中科院分区：
文献类型：
--
作者：
El Khoudary, Samar R;Nasr, Alexis
众所周知，绝经过渡期（MT）是女性生命中的一个复杂时期，但关于中年期间心血管疾病（CVD）的增加是否是由于时间老化或卵巢老化引起的一直存在争议。本文综述了近年来卵巢老化与年龄老化对女性心血管疾病（CVD）结局及其危险因素的影响。最近来自纵向研究的数据表明，绝经相关因素，如绝经年龄较早和手术绝经与较高的CVD结局相关。MT还与血管健康的有害变化以及心脏代谢风险因素相关，包括身体成分、内脏脂肪堆积、脂质/脂蛋白、血压和代谢综合征。最近研究的有力证据表明，随着年龄的增长，MT的心血管疾病风险增加，这要求立即努力提高妇女及其医疗保健提供者对伴随MT的心血管疾病风险加速的认识。还应努力开发和测试针对这一时期妇女的新的预防方法，以抵消心血管疾病风险的预期增加。
It is known that the menopause transition (MT) is a complex period during a woman's life, but there has been ongoing debate on whether the increase in cardiovascular disease (CVD) during midlife is due to chronological aging or ovarian aging. The purpose of this review is to summarize the recent findings on the role of ovarian aging versus chronological aging on cardiovascular disease (CVD) outcomes and its risk factors in women. Recent data from longitudinal studies have shown that menopause-related factors, such as earlier age at menopause and surgical menopause are associated with higher CVD outcomes. The MT is also associated with detrimental changes in vascular health as well as cardiometabolic risk factors including body composition, visceral fat accumulation, lipids/lipoproteins, blood pressure and the metabolic syndrome. The robust evidence from recent research indicating increases in CVD risk over the MT beyond aging call for immediate efforts to rise awareness among women and their health care providers of CVD risk acceleration accompanying the MT. Efforts should also be directed toward developing and testing novel preventive approaches that target women during this time period to counteract the expected increase in CVD risk.