Receptive-field and axonal properties of neurons in the dorsal lateral geniculate nucleus of awake unparalyzed rabbits.
Receptive-field and axonal properties of neurons in the dorsal lateral geniculate nucleus of awake unparalyzed rabbits.
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清醒未瘫痪兔子背外侧膝状核神经元的感受野和轴突特性。
DOI：
10.1152/jn.1985.54.1.168
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发表时间：
1985
影响因子：
2.5
通讯作者：
T. Weyand
中科院分区：
文献类型：
--
作者：
H. Swadlow;T. Weyand
利用兔眼的内在稳定性，使LGNd神经元和视束轴突在清醒，未麻痹状态下的感受场分析。我们发现眼睛的位置保持在小于1.0度的范围内的时间为4 - 5分钟，在某些情况下，在超过10分钟的时间内。这种稳定性是在清醒的猴子，已被训练的固定相媲美。背外侧膝状体核（LGNd）神经元的感受野进行了分析，约84%的同心组织。这是一个比以前在该物种中报道的更高的值。此外，同心圆细胞的感受野中心比以前报道的要小得多（平均直径= 2.5度）。LGNd中的大多数剩余神经元是方向选择性的（6.5%）或运动/均匀的（6.5%）。基于对站立对比的反应持续时间，将同心圆细胞分类为持续的或短暂的。在LGNd的持续同心细胞的感受野主要是水平子午线附近，内的代表性的视觉条纹，而瞬态同心细胞的感受野的位置更普遍的在上视野。在视束的持续和短暂的细胞的感受野的位置分布更均匀，比在LGNd。LGNd中持续和短暂的同心细胞主要表现为非线性空间总和。LGNd神经元的感受野特性与膝状皮质逆行潜伏期有关。大多数LGNd神经元的所有感受场类投射轴突的视觉皮层。因此，任何内在的中间神经元在兔LGNd可能有类似的一些主要神经元的感受场特性。在不同感受野类别的神经元中，逆向电流的分布有明显的重叠。然而，同心持续神经元的传导速度确实比同心瞬时神经元慢。非视觉感官刺激，导致脑电图唤醒（海马theta活动）的反应时间的影响深远的大多数（28/32）持续同心神经元。对于这些细胞，持续反应站立对比开始减少，有时消失后2 - 15秒。然而，引起海马theta活动的刺激重新建立了持续的反应。在没有视觉刺激的情况下，这种唤醒刺激通常对细胞的放电影响很小或没有影响。唤醒刺激对具有持续同心感受野特性的视束轴突没有影响。（400字处截断摘要）
The intrinsic stability of the rabbit eye was exploited to enable receptive-field analysis of LGNd neurons and optic tract axons in the awake, unparalyzed state. We found eye position to remain within a range of less than 1.0 degrees for periods of 4-5 min, and in some cases for periods in excess of 10 min. Such stability is comparable to that seen in awake monkeys that have been trained to fixate. Receptive fields of dorsal lateral geniculate nucleus (LGNd) neurons were analyzed, and approximately 84% were concentrically organized. This is a higher value than previously reported in this species. In addition, the receptive-field centers of concentric cells were much smaller than those previously reported (mean diameter = 2.5 degrees). Most remaining neurons in the LGNd were either directionally selective (6.5%) or motion/uniform (6.5%). Concentric cells were classified as sustained or transient based on response duration to standing contrast. In the LGNd the receptive fields of sustained concentric cells were predominantly near the horizontal meridian, within the representation of the visual streak, while the receptive-field positions of transient concentric cells were more prevalent in the upper visual field. In the optic tract the receptive-field positions of both sustained and transient cells were more evenly distributed than was seen in the LGNd. Sustained and transient concentric cells in LGNd showed primarily nonlinear spatial summation. The receptive-field properties of LGNd neurons were related to geniculocortical antidromic latency. Most LGNd neurons of all receptive-field classes projected axons to the visual cortex. Thus, any intrinsic interneurons in the rabbit LGNd may have receptive-field properties similar to those of some principal neurons. There was significant overlap in the distribution of antidromic latencies in neurons of different receptive-field classes. Concentric sustained neurons, however, did conduct somewhat more slowly than did concentric transient neurons. Nonvisual sensory stimuli that resulted in EEG arousal (hippocampal theta activity) had a profound effect on the response duration of most (28/32) sustained concentric neurons. For these cells, the sustained response to standing contrast began to diminish and sometimes disappeared after 2-15 s. However, arousing stimuli that resulted in hippocampal theta activity reestablished the sustained response. Such arousing stimuli usually had little or no effect on the discharge of the cell in the absence of visual stimuli. Arousing stimuli had no effect on optic tract axons with sustained concentric receptive-field properties.(ABSTRACT TRUNCATED AT 400 WORDS)