Effect of surface-functionalized nanoparticles on the elongation phase of beta-amyloid (1-40) fibrillogenesis
Effect of surface-functionalized nanoparticles on the elongation phase of beta-amyloid (1-40) fibrillogenesis
复制标题
DOI：
10.1016/j.biomaterials.2012.03.024
复制
发表时间：
2012-06-01
期刊：
影响因子：
14
通讯作者：
Li, Hung-Wing
中科院分区：
文献类型：
--
作者：
Chan, Ho-Man;Xiao, Lehui;Li, Hung-Wing
研究了不同尺寸和表面官能度的纳米颗粒对β-淀粉样蛋白（1-40）肽自组装成纤维的影响。在种子介导的生长方法下，将包括量子点和金纳米颗粒的功能化纳米颗粒与单体A β（1-40）肽共孵育，以研究它们对纤维形成的延伸阶段的影响。结果表明，纳米颗粒与功能基团的荷表面积比以及颗粒表面共轭配体的静电荷在A β（1-40）纤维形成中起着重要的调控作用。(C)2012爱思唯尔有限公司保留所有权利。
The influence of nanoparticles of various sizes and surface functionalities on the self-assembling fibrillogenesis of beta-amyloid (1-40) peptide was investigated. Functionalized nanoparticles including quantum dots and gold nanoparticles were co-incubated with monomeric A beta(1-40) peptides under seed-mediated growth method to study their influences on the elongation phase of the fibrillogenesis. It is observed that charge-to-surface area ratio of the nanoparticles and the functional moiety and electrostatic charges of the conjugated ligands on the particle surfaces took crucial regulatory role in the A beta(1-40) fibrillogenesis. (C) 2012 Elsevier Ltd. All rights reserved.