Control of oscillation periods and phase durations in half-center central pattern generators: a comparative mechanistic analysis.
Control of oscillation periods and phase durations in half-center central pattern generators: a comparative mechanistic analysis.
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半中心中心图案发生器中振荡周期和相位持续时间的控制：比较机械分析。
DOI：
10.1007/s10827-008-0124-4
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发表时间：
2009-08
影响因子：
1.2
通讯作者：
Rybak, Ilya A.
中科院分区：
文献类型：
--
作者：
Daun, Silvia;Rubin, Jonathan E.;Rybak, Ilya A.
关键词：
中枢模式发生器（centralpatterngenerators，CPG）是由相互作用的神经元群组成，在无脊椎动物和脊椎动物中驱动着各种重复的、有节律的行为，如运动、呼吸、咀嚼、抓挠等，这些CPG能够在没有传入反馈或节律输入的情况下产生节律性活动。然而，功能相关的CPG必须自适应地响应于不断变化的需求，表现为响应于非模式化输入或驱动的变化而在振荡周期或相对相位持续时间中的变化。虽然已经提出了许多半中心CPG模型，由相互抑制连接的对称单元组成，但其内在的细胞特性各不相同，但大多数生物CPG中的精确振荡机制仍然未知。通过数值模拟和相平面分析，我们比较研究了不同CPG模型中的内在细胞特征，如基于缓慢失活持续钠电流的阈下激活，基于缓慢激活钙依赖性钾电流的适应，或抑制后反弹兴奋，可以有助于控制响应于对一个或两个半中心的兴奋性外部驱动的变化的振荡周期和相位持续时间。我们的分析表明，无论是敏感性的振荡周期的兴奋性驱动的变化和程度，每个阶段的持续时间可以单独控制强烈依赖于内在的细胞机制参与节奏的产生和相变。特别是，CPG形成的单位纳入一个缓慢失活的持续钠电流显示最大范围的振荡周期和最大程度的独立性，在相位持续时间控制的不对称输入。这些结果解释的基础上的相平面结构的几何分析对应的动力学为每个CPG类型，这特别有助于查明逃逸和释放突触抑制的作用，我们发现。
Central pattern generators (CPGs) consisting of interacting groups of neurons drive a variety of repetitive, rhythmic behaviors in invertebrates and vertebrates, such as arise in locomotion, respiration, mastication, scratching, and so on. These CPGs are able to generate rhythmic activity in the absence of afferent feedback or rhythmic inputs. However, functionally relevant CPGs must adaptively respond to changing demands, manifested as changes in oscillation period or in relative phase durations in response to variations in non-patterned inputs or drives. Although many half-center CPG models, composed of symmetric units linked by reciprocal inhibition yet varying in their intrinsic cellular properties, have been proposed, the precise oscillatory mechanisms operating in most biological CPGs remain unknown. Using numerical simulations and phase-plane analysis, we comparatively investigated how the intrinsic cellular features incorporated in different CPG models, such as sub-threshold activation based on a slowly inactivating persistent sodium current, adaptation based on slowly activating calcium-dependent potassium current, or post-inhibitory rebound excitation, can contribute to the control of oscillation period and phase durations in response to changes in excitatory external drive to one or both half-centers. Our analysis shows that both the sensitivity of oscillation period to alterations of excitatory drive and the degree to which the duration of each phase can be separately controlled depend strongly on the intrinsic cellular mechanisms involved in rhythm generation and phase transitions. In particular, the CPG formed from units incorporating a slowly inactivating persistent sodium current shows the greatest range of oscillation periods and the greatest degree of independence in phase duration control by asymmetric inputs. These results are explained based on geometric analysis of the phase plane structures corresponding to the dynamics for each CPG type, which in particular helps pinpoint the roles of escape and release from synaptic inhibition in the effects we find.
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影响因子：
2.4
作者：
Rubin, Jonathan E.
通讯作者：
Rubin, Jonathan E.
影响因子：
1.2
作者：
Rubin, JE;Terman, D
通讯作者：
Terman, D
影响因子：
2.5
作者：
Shpiro, Asya;Curtu, Rodica;Rubin, Nava
通讯作者：
Rubin, Nava
影响因子：
5.5
作者：
Rybak, Ilya A.;Shevtsova, Natalia A.;McCrea, David A.
通讯作者：
McCrea, David A.
影响因子：
2.1
作者：
Curtu, Rodica;Shpiro, Asya;Rinzel, John
通讯作者：
Rinzel, John