Dendritic Cells in Cardiovascular Diseases Epiphenomenon, Contributor, or Therapeutic Opportunity
Dendritic Cells in Cardiovascular Diseases Epiphenomenon, Contributor, or Therapeutic Opportunity
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DOI：
10.1161/circulationaha.113.003364
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发表时间：
2013-12-17
期刊：
影响因子：
37.8
通讯作者：
Biessen, Erik A. L.
中科院分区：
文献类型：
--
作者：
Christ, Anette;Temmerman, Lieve;Biessen, Erik A. L.
作为DC与CVD相关性的间接测量，已经在患有CVD（例如冠状动脉和外周动脉疾病）的患者的血液中评估了DC数量和功能。[15] 2006年，货车Vre及其同事首次描述了冠状动脉疾病（CAD）患者的循环DC（循环cDC和pDC）显著减少，血管造影定义为≥ 1支冠状动脉狭窄> 50%。16到目前为止，几项研究证实了CAD患者血液DC（cDC和pDC）的显著减少，无论CAD级别（稳定型与不稳定型心绞痛，急性心肌梗死），病变血管数量或用于DC计数的子集标记物如何。15，17-23与此形成鲜明对比的是，Shi和同事24报道了稳定型CAD患者中循环cDC增加，pDC数量不变。通过研究不同阶段外周动脉疾病患者（包括间歇性跛行和严重肢体缺血患者）循环DC的分布，Dopheide及其同事25发现，与健康对照组相比，外周动脉疾病患者的血液cDC数量增加，而pDC数量减少。值得注意的是，严重肢体缺血患者的cDCs和pDCs都显示出不成熟的表型，这表明这种疾病中严重的缺血和长期的炎症可能导致循环DC亚群的促炎膜模式的衰减。不一致的结果可能是由于疾病的程度和部位、采血时间（手术干预前/后;病变发作与进展）、这些研究中纳入的患者的风险因素患病率以及咨询的队列规模存在差异。
As an indirect measure of DCs' association with CVD, DC numbers and functionality have been evaluated in the blood of patients with CVD, such as coronary and peripheral artery disease. 15 In 2006, van Vre and coworkers were the first to describe a marked decrease in circulating DCs (circulating cDCs and pDCs) in patients with coronary artery disease (CAD), defined by angiography as> 50% stenosis in≥ 1coronary arteries. 16 Until now, several studies confirmed a significant decrease in blood DCs (cDCs and pDCs) in CAD patients, irrespective of CAD grade (stable versus unstable angina pectoris, acute myocardial infarction), number of diseased vessels, or subset markers used for DC enumeration. 15, 17–23 In sharp contrast, Shi and colleagues24 reported increased circulating cDCs and unaltered pDC numbers in patients with stable CAD. By investigating the distribution of circulating DCs in patients with different stages of peripheral arterial disease, including patients with intermittent claudication and critical limb ischemia, Dopheide and coworkers25 showed that blood cDC numbers were increased, whereas pDC numbers were reduced in patients who had peripheral arterial disease in comparison with healthy controls. Of note, both cDCs and pDCs from patients who have critical limb ischemia revealed an immature phenotype, suggesting that severe ischemia and prolonged inflammation in this ailment might lead to an attenuation in the proinflammatory membrane patterns of circulating DC subsets.In general, most patient studies show declined blood DC numbers in CAD patients. Inconsistent results may be explained by differences in the extent and localization of disease, the timing of blood sampling (before/after a surgical intervention; lesion onset versus progression), the prevalence of risk factors across the patients included in these studies, and the cohort sizes consulted.