Enterotoxigenic Escherichia coli diarrhoea: acquired immunity and transmission in an endemic area.
Enterotoxigenic Escherichia coli diarrhoea: acquired immunity and transmission in an endemic area.
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产肠毒素大肠杆菌腹泻：流行地区的获得性免疫和传播。
DOI：
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发表时间：
1981
影响因子：
11.1
通讯作者：
D. Sack
中科院分区：
文献类型：
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作者：
R. E. Black;M. Merson;B. Rowe;P. Taylor;A. Alim;R. Gross;D. Sack
产肠毒素大肠杆菌（ETEC）是发展中国家腹泻的一个重要原因。在孟加拉国的一个流行区，对与大肠杆菌产生热稳定和不耐热毒素（ST/LT）或仅热稳定毒素（ST）有关的腹泻患者的家庭接触者进行了研究。研究发现，在10天的研究期间，11%的接触者被感染，感染率和感染腹泻的人的比例都随着年龄的增长而下降，这表明免疫力的发展。在指数家庭使用的9%的水源、指数家庭的少数食物和饮用水样本以及3头健康小牛的粪便中发现了与指数患者相同血清型的ETEC。在有受污染食物或水的房屋中，家庭成员的感染率最高，这表明当被污染的水带入家中时，感染可能发生在家中。
Enterotoxigenic Escherichia coli (ETEC) are an important cause of diarrhoea in developing countries. Studies were made, in an endemic area of Bangladesh, of household contacts of patients with diarrhoea associated with E. coli producing heat-stable and heatlabile toxins (ST/LT) or heat-stable toxin (ST) only. It was found that 11% of contacts were infected in the 10-day study period, and that both the rate of infection and the proportion of infected persons with diarrhoea decreased with increasing age, suggesting the development of immunity. ETEC of the same serotype as that of the index patient were found in 9% of water sources used by index households, in a small number of food and drinking water specimens from the index homes, and in faeces from 3 healthy calves. The rate of infection of household members was highest in houses where there was contaminated food or water, which suggests that infection may take place in the home when contaminated water is brought in.