Synthesis of functionalized spiroheterocycles by sequential multicomponent reaction/metal-catalyzed carbocylizations from simple β-ketoesters and amides
Synthesis of functionalized spiroheterocycles by sequential multicomponent reaction/metal-catalyzed carbocylizations from simple β-ketoesters and amides
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DOI：
10.1055/s-2007-973896
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发表时间：
2007-04-24
期刊：
影响因子：
2
通讯作者：
Rodriguez, Jean
中科院分区：
文献类型：
--
作者：
Habib-Zahmani, Hadjira;Viala, Jacques;Rodriguez, Jean
报道了一种新的策略，从简单的环状β-酮酯或酰胺，包括选择性的三组分反应和闭环复分解或钯催化的碳环化，以顺序的方式获得螺杂环。这种有利的两步序列从简单和容易获得的起始材料产生具有显著分子复杂性和高度合成和生物相关性的化合物。
A new strategy from simple cyclic beta-ketoesters or amides involving a selective three-component reaction and a ring-closing metathesis or a palladium-catalyzed carbocyclization in a sequential fashion to access spiroheterocycles is reported. This expedient two-step sequence generates compounds of significant molecular complexity and high synthetic and biological relevance from simple and readily available starting materials.