Association between MTHFR C677T polymorphism and risk of acute lymphoblastic leukemia: a meta-analysis based on 51 case-control studies.
Association between MTHFR C677T polymorphism and risk of acute lymphoblastic leukemia: a meta-analysis based on 51 case-control studies.
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DOI：
10.12659/msm.892835
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发表时间：
2015-03-12
期刊：
影响因子：
--
通讯作者：
Yang M
中科院分区：
文献类型：
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作者：
Li SY;Ye JY;Liang EY;Zhou LX;Yang M
关于5，10-亚甲基四氢叶酸还原酶（MTHFR）C677 T多态性在急性淋巴细胞白血病（ALL）风险中的作用，研究和系统评价得出了不一致的结论。为探讨MTHFR C677 T基因多态性与急性淋巴细胞白血病（ALL）的关系，对纳入的51篇病例对照研究（包括7892例病例和14280例对照）进行Meta分析。在显性模型中发现了统计学差异（TT+CT vs. CC，比值比（OR）=0.89，95%CI，0.79-1.00，P=0.04），CT vs. CC（OR=0.89，95%CI，0.80-1.00，P=0.05），但在等位基因对比模型中未发现（T vs. C，OR=0.92，95% CI，0.84-1.01，P=0.08），相加模型（TT vs. CC，OR=0.87，95%CI，0.73-1.05，P=0.15）或隐性模型（TT vs. CT+CC，OR=0.94，95%CI，0.81-1.10，P=0.44）。在按年龄（儿童和成人）和种族（亚洲人和高加索人）分层的亚组分析中，未观察到MTHFR C677 T多态性与ALL风险之间的显著相关性。本研究未发现MTHFR C677 T多态性在ALL易感性中具有保护作用的充分证据。
Studies and systematic reviews have reached inconsistent conclusions on the role of 5, 10-methylenetetrahydrofolate reductase (MTHFR) polymorphism C677T in acute lymphoblastic leukemia (ALL) risk. The present meta-analysis comprising of 51 case-control studies, including 7892 cases and 14 280 controls was performed to reevaluate the association between MTHFR C677T polymorphism and ALL risk. Statistical differences were found in the dominant model (TT+CT vs. CC, odd ratio (OR)=0.89, 95% CI, 0.79–1.00, P=0.04) and the CT vs. CC (OR=0.89, 95% CI, 0.80–1.00, P=0.05), but not in the allele contrast model (T vs. C, OR=0.92, 95% CI, 0.84–1.01, P=0.08), additive model (TT vs. CC, OR=0.87, 95% CI, 0.73–1.05, P=0.15), or recessive model (TT vs. CT+CC, OR=0.94, 95% CI, 0.81–1.10, P=0.44) in overall populations. In the subgroup analyses stratified by age (children and adults) and ethnicity (Asian and Caucasian), no significant associations between MTHFR C677T polymorphism and ALL risk were observed. The current study found no sufficient evidence of a protective role of MTHFR C677T polymorphism in ALL susceptibility.