Impact of healthy lifestyle on mortality in people with normal blood pressure, LDL cholesterol, and C-reactive protein
Impact of healthy lifestyle on mortality in people with normal blood pressure, LDL cholesterol, and C-reactive protein
复制标题
DOI：
10.1177/1741826711425776
复制
发表时间：
2013-02-01
影响因子：
8.3
通讯作者：
Everett, Charles J.
中科院分区：
文献类型：
--
作者：
King, Dana E.;Mainous, Arch G., III;Everett, Charles J.
背景：旨在调查健康生活方式对没有心血管疾病史且没有脂质、血压或炎症标志物升高的人群的心血管风险和死亡率的影响。设计：队列研究。方法：对 NHANES III 随访死亡率调查中的不同成年人样本进行研究，以确定坚持健康生活习惯（每天五种或更多水果和蔬菜、定期锻炼或不肥胖（体重指数 18.5-29.9）的益处。 kg/m(2)）、目前不吸烟、适度饮酒），且没有常见心血管危险因素，如胆固醇升高（低密度脂蛋白，LDL，胆固醇> 130 mg/dl），炎症（C反应蛋白，CRP，> 3.0 mg/l，或高血压（血压> 140/90 mmHg）。结果：在11,841名参与者中，14.9％坚持所有五种健康习惯。控制年龄、种族和性别后，低密度脂蛋白胆固醇较低（HR 6.33，95% CI 2.80-14.30）、低CRP（HR 3.48，95% CI 2.23-5.41）或血压正常（HR 2.87，95% CI 1.58-5.20）和0-1健康习惯的个体的全因死亡率（如图所示）和心血管死亡率显着较高没有常见危险因素且仅缺乏 1-2 种健康习惯的人，其全因死亡风险仍然较高。结论：没有心血管病史且缺乏常见心血管危险因素的人，如果不坚持健康的生活方式，则应在所有风险水平的个人中实施鼓励采取健康生活方式的策略。
Background: To investigate the impact of healthy lifestyle on cardiovascular risk and mortality in people without a history of cardiovascular disease and without elevation of lipid, blood pressure, or inflammatory markers.Design: Cohort study.Methods: Study of a diverse sample of adults in the NHANES III follow-up Mortality Survey, to determine the benefit of adhering to healthy lifestyle habits (five or more fruits and vegetables/day, regular exercise, or being non-obese (body mass index 18.5-29.9 kg/m(2)), no current smoking, moderate alcohol consumption) in adults without common cardiovascular risk factors such as elevated cholesterol (low-density lipoprotein, LDL, cholesterol > 130 mg/dl), inflammation (C-reactive protein, CRP, > 3.0 mg/l, or hypertension (blood pressure > 140/90 mmHg).Results: Of 11,841 participants, 14.9% were adherent to all five healthy habits. After controlling for age, race, and gender, individuals with lower LDL cholesterol (HR 6.33, 95% CI 2.80-14.30), low CRP (HR 3.48, 95% CI 2.23-5.41), or normal blood pressure (HR 2.87, 95% CI 1.58-5.20) and 0-1 healthy habits had significantly higher all-cause (shown) and cardiovascular mortality than people adhering to all five healthy habits. People without common risk factors and lacking only 1-2 of the healthy habits remained at higher risk of all-cause mortality.Conclusions: People without a history of cardiovascular disease who lack common cardiovascular risk factors remain at significantly greater risk of cardiovascular and all-cause mortality if they do not adhere to a healthy lifestyle. Strategies to encourage adopting healthy lifestyles should be implemented among individuals across all risk levels.