Mechano-acoustic sensing of physiological processes and body motions via a soft wireless device placed at the suprasternal notch
Mechano-acoustic sensing of physiological processes and body motions via a soft wireless device placed at the suprasternal notch
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DOI：
10.1038/s41551-019-0480-6
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发表时间：
2020-02-01
影响因子：
28.1
通讯作者：
Rogers, John A.
中科院分区：
文献类型：
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作者：
Lee, KunHyuck;Ni, Xiaoyue;Rogers, John A.
结合高带宽三轴加速度计的皮肤安装软电子器件可以捕获广泛的生理相关信息，包括潜在身体过程的机械声学签名（例如由听诊器测量的那些）和核心身体运动的精确运动学。在这里，我们描述了一种设计成共形放置在胸骨上切迹上的无线设备，用于连续测量机械声学信号，从大约10（-3）ms（-2）加速度的皮肤的细微振动到大约10 ms（-2）的整个身体的大运动，并且频率高达大约800 Hz。由于测量是由运动、身体定向、吞咽、呼吸、心脏活动、声带振动和其他来源产生的信号的复杂叠加，我们利用频域分析和机器学习从自然日常活动和锻炼期间的人类受试者获得心率、呼吸率、能量强度和其他基本生命体征的实时记录，以及说话时间和节奏、吞咽计数和模式以及其他非常规生物标志物。我们还在睡眠实验室中使用了该设备，并使用多导睡眠图验证了测量结果。被设计成共形地放置在胸骨上切迹上的无线设备可以连续地提供基本生命体征以及通话时间、吞咽计数和睡眠模式的实时信息。
Skin-mounted soft electronics that incorporate high-bandwidth triaxial accelerometers can capture broad classes of physiologically relevant information, including mechano-acoustic signatures of underlying body processes (such as those measured by a stethoscope) and precision kinematics of core-body motions. Here, we describe a wireless device designed to be conformally placed on the suprasternal notch for the continuous measurement of mechano-acoustic signals, from subtle vibrations of the skin at accelerations of around 10(-3)ms(-2) to large motions of the entire body at about 10ms(-2), and at frequencies up to around 800Hz. Because the measurements are a complex superposition of signals that arise from locomotion, body orientation, swallowing, respiration, cardiac activity, vocal-fold vibrations and other sources, we exploited frequency-domain analysis and machine learning to obtain-from human subjects during natural daily activities and exercise-real-time recordings of heart rate, respiration rate, energy intensity and other essential vital signs, as well as talking time and cadence, swallow counts and patterns, and other unconventional biomarkers. We also used the device in sleep laboratories and validated the measurements using polysomnography. A wireless device designed to be conformally placed on the suprasternal notch can continuously provide real-time information of essential vital signs as well as talking time, swallow counts and sleep patterns.