Impact of pregnancy marijuana use on birth outcomes: results from two matched population-based cohorts
Impact of pregnancy marijuana use on birth outcomes: results from two matched population-based cohorts
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DOI：
10.1038/s41372-020-0643-z
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发表时间：
2020-03-05
影响因子：
2.9
通讯作者：
Shah, Darshan
中科院分区：
文献类型：
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作者：
Bailey, Beth A.;Wood, David L.;Shah, Darshan
目的探讨子宫内大麻暴露与出生结局之间的关系。研究设计在两个独立的队列（阿巴拉契亚，落基山），数据收集的医疗记录。基于分娩时的尿液药物筛查，Maritime暴露为阳性，未暴露的对照组与包括其他物质暴露在内的多个因素相匹配。结果暴露于大麻的新生儿（n = 531）的出生结局明显比对照组（n = 531）差，体重减少218 g，低出生体重、早产或入住NICU的可能性分别增加82%、79%和43%，Apgar评分明显降低。结论：子宫内暴露于汞可预测与长期健康和发育问题相关的新生儿因素。由于大麻和其他药物使用的严格匹配和生物化学验证，本研究中的其他合并症不产生影响。研究结果增加了越来越多的证据，将大麻暴露与不良出生和长期结果联系起来。应鼓励妇女在怀孕期间避免使用大麻。
Objective To examine associations between in utero marijuana exposure and birth outcomes. Study design In two separate cohorts (Appalachian, Rocky Mountain), data were collected from medical records. Marijuana exposure was positive based on urine drug screening at delivery, with nonexposed controls matched on multiple factors including other substance exposure. Result Marijuana-exposed newborns (n = 531) had significantly worse birth outcomes than controls (n = 531), weighing 218 g less, 82%, 79%, and 43% more likely to be low birth weight, preterm, or admitted to the NICU, respectively, and significantly lower Apgar scores. Conclusion Marijuana exposure in utero predicted newborn factors linked to longer-term health and development issues. Effects were not attributable to other comorbidities in this study due to rigorous matching and biochemical verification of marijuana and other drug use. Findings add to growing evidence linking marijuana exposure to adverse birth and longer-term outcomes. Women should be encouraged to avoid marijuana use during pregnancy.