On the possibility of estimating myocardial fiber architecture from cardiac strains.
On the possibility of estimating myocardial fiber architecture from cardiac strains.
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DOI：
10.1007/978-3-031-35302-4_8
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发表时间：
2023-06
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影响因子：
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通讯作者：
Avazmohammadi R
中科院分区：
文献类型：
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作者：
Usman M;Mendiola EA;Mukherjee T;Mehdi RR;Ohayon J;Alluri PG;Sadayappan S;Choudhary G;Avazmohammadi R
心肌由收缩性肌纤维的复杂网络组成，这些收缩性肌纤维以产生心脏的有效收缩和舒张的方式组织。心肌中的肌纤维结构是心脏运动和心脏的整体或器官水平功能的关键决定因素。心脏疾病（如肺动脉高压和心肌梗死）的结构重塑报告可能导致心功能不全，因此需要纳入结构标志物以改善心脏功能评估。然而，三维肌结构的体内量化已被证明具有挑战性。在这项工作中，我们研究的敏感性，心脏应变不同的肌纤维方向使用多尺度有限元模型的LV。此外，我们提出了一种逆建模方法来预测心肌纤维结构的心脏应变。我们的研究结果表明，纤维取向和左心室运动学之间有很强的相关性，证实了纤维结构是左心室收缩行为的主要决定因素。我们的逆模型能够准确地预测心肌纤维范围和区域纤维角度的应变措施。对LV肌纤维结构和运动之间联系的具体理解，以及表征心肌结构的非侵入性和可行方法的开发，预计将导致先进的LV功能指标和改善结构性心脏病的预后评估。
The myocardium is composed of a complex network of contractile myofibers that are organized in such a way as to produce efficient contraction and relaxation of the heart. The myofiber architecture in the myocardium is a key determinant of cardiac motion and the global or organ-level function of the heart. Reports of architectural remodeling in cardiac diseases, such as pulmonary hypertension and myocardial infarction, potentially contributing to cardiac dysfunction call for the inclusion of an architectural marker for an improved assessment of cardiac function. However, the in-vivo quantification of three-dimensional myo-architecture has proven challenging. In this work, we examine the sensitivity of cardiac strains to varying myofiber orientation using a multiscale finite-element model of the LV. Additionally, we present an inverse modeling approach to predict the myocardium fiber structure from cardiac strains. Our results indicate a strong correlation between fiber orientation and LV kinematics, corroborating that the fiber structure is a principal determinant of LV contractile behavior. Our inverse model was capable of accurately predicting the myocardial fiber range and regional fiber angles from strain measures. A concrete understanding of the link between LV myofiber structure and motion, and the development of non-invasive and feasible means of characterizing the myocardium architecture is expected to lead to advanced LV functional metrics and improved prognostic assessment of structural heart disease.