A Bioinspired Medical Adhesive Derived from Skin Secretion of Andrias davidianus for Wound Healing
A Bioinspired Medical Adhesive Derived from Skin Secretion of Andrias davidianus for Wound Healing
复制标题
源自大鲵皮肤分泌物的仿生医用粘合剂，用于伤口愈合
DOI：
10.1002/adfm.201809110
复制
发表时间：
2019-08-01
影响因子：
19
通讯作者：
Tan, Hong
中科院分区：
文献类型：
--
作者：
Deng, Jun;Tang, Yingying;Tan, Hong
市场上现有的外科组织粘合剂由于其粘附性有限或不需要的细胞毒性，不能满足临床手术的需要。一种新的生物粘附剂是从大蚂蚁(Andrias Davidianus)皮肤分泌物中提取的。这种生物启发的SSAD比纤维蛋白胶具有更强的组织粘附力，与氰基丙烯酸酯胶体内外相比，弹性和生物相容性都得到了改善。此外，基于SSAD的粘合剂可缩短皮肤伤口愈合时间，促进伤口再生和血管生成。基于SSAD的粘合剂是完全可降解的，粘结力强，很容易从可再生来源生产。基于这些良好的性能，基于SSAD的生物粘合剂在广泛的医疗应用中显示出作为外科生物粘合剂的潜力。
Existing surgical tissue adhesives on the market cannot meet the desired demand for clinical operations due to their limited adhesivity or undesired cytotoxicity. A new bioadhesive is derived from the skin secretion of Andrias davidianus (SSAD). This bioinspired SSAD has significantly stronger tissue adhesion than the fibrin glue and improved elasticity and biocompatibility when compared to the cyanoacrylate glue both ex vivo and in vivo. Additionally, the SSAD‐based adhesive decreases skin wound healing time and promotes wound regeneration and angiogenesis. The SSAD‐based adhesive is completely degradable, strongly adhesive, and easily produced from a renewable source. Based on these favorable properties, the SSAD‐based bioadhesive demonstrates potential as a surgical bioadhesive for a broad range of medical applications.