Platelet kinetics.
Platelet kinetics.
复制标题
血小板动力学。
DOI：
10.1097/00062752-199704050-00006
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Dale,GL
中科院分区：
文献类型：
--
作者：
Dale,GL
使用放射性同位素方法可以相当精确地确定血小板存活率;然而，与这些技术相关的并发症仍然催化了对非同位素程序的搜索，以估计血小板存活率以及血小板寿命的替代标志物。最近关于血小板年龄标志物的报道主要集中在噻唑橙染色计数“网织血小板”，即残留mRNA的年轻血小板。许多临床研究已经观察到噻唑橙阳性血小板和血小板合成之间的相关性，从而提供了一种非侵入性的手段来区分血小板减少症的合成和破坏机制。此外，最近在动物系统中开发了用于定量血小板存活的非同位素方法，尽管它们尚未转移到人类使用。最后，与血小板周转相关的一个辅助主题是细胞年龄对血小板反应性的影响。最近对白细胞介素-6等细胞因子的研究使有关年龄和反应性的流行范式变得复杂，这些研究表明血小板年龄并不是血小板反应性的唯一决定因素。
Platelet survival can be determined with considerable precision using radioisotopic methodologies; however, complications associated with these techniques still catalyze the search for nonisotopic procedures to estimate platelet survival as well as surrogate markers of platelet life span. Recent reports on markers of platelet age have focused on thiazole orange-staining for enumeration of “reticulated platelets,” ie, young platelets with residual mRNA. Numerous clinical studies have observed a correlation between thiazole orange-positive platelets and platelet synthesis, thereby providing a noninvasive means to differentiate between synthetic and destructive mechanisms in thrombocytopenia. Additionally, nonisotopic methods for quantitating platelet survival have recently been developed in animal systems, although they have not yet been transferred to human use. And finally, an ancillary topic related to platelet turnover is the impact of cell age on platelet reactivity. Prevailing paradigms concerning age and reactivity are complicated by recent studies with cytokines, such as interleukin-6, which demonstrate that platelet age is not the sole determinant of platelet reactivity.