Aberrant inflammatory profile in acute but not recovered anorexia nervosa
Aberrant inflammatory profile in acute but not recovered anorexia nervosa
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DOI：
10.1016/j.bbi.2020.05.024
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发表时间：
2020-08-01
影响因子：
15.1
通讯作者：
Landen, Mikael
中科院分区：
文献类型：
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作者：
Nilsson, Ida A. K.;Millischer, Vincent;Landen, Mikael
神经性厌食症（AN）是一种严重的精神疾病，具有高死亡率和复发率。尽管已知炎性标志物和细胞因子的变化伴随与躯体疾病如癌症和慢性肾病相关的恶病质，但关于AN中炎性标志物的研究很少，通常包括很少的个体。在这里，我们利用Olink蛋白质组学炎症组来探索来自患有活动性AN（N = 113）、从AN（AN-REC，N = 113）恢复的女性和正常体重健康对照（N = 114）的血浆样品中92种预选的炎症相关蛋白的浓度。在对多重检测进行校正后，25种蛋白质在AN组和对照组之间存在显著差异（较低水平：ADA、CCL 19、CD 40、CD 5、CD 8A、CSF 1、CXCL 1、CXCL 5、HGF、IL 10 RB、IL 12 B、IL 18 R1、TGF β 1、MCP 3、OSM、TGF α、TNFRSF 9、TNFS 14和TRANCE;较高水平：CCL 11、CCL 25、CST 5、DNER、LIFR和OPG）。虽然一半以上的这些差异（N=15）存在于AN和AN-REC之间的比较中，但AN-REC和对照组之间没有显著差异。此外，25种蛋白质与BMI呈正相关ADA、AXIN 1、CASP 8、CD 5、CD 40、CSF 1、CXCL 1、CXCL 5、EN-BRA、HGF、IL 6、IL 10 RB、IL 12 B、IL 18、IL 18 R1、TGF β 1、OSM、SIRT 2、STAMBP、TGF α、TNFRSF 9、TNFS 14、TRANCE、TRAIL和VEGFA四种蛋白与BMI呈负相关这些结果表明，失调的炎症状态与AN相关，但重要的是，似乎仅限于急性疾病状态。
Anorexia nervosa (AN) is a severe psychiatric disorder with high mortality and relapse rates. Even though changes in inflammatory markers and cytokines are known to accompany cachexia associated with somatic disorders such as cancer and chronic kidney disorder, studies on inflammatory markers in AN are rare and typically include few individuals. Here, we utilize an Olink Proteomics inflammatory panel to explore the concentrations of 92 preselected inflammation-related proteins in plasma samples from women with active AN (N = 113), recovered from AN (AN-REC, N = 113), and normal weight healthy controls (N = 114). After correction for multiple testing, twenty-five proteins differed significantly between the AN group and controls (lower levels: ADA, CCL19, CD40, CD5, CD8A, CSF1, CXCL1, CXCL5, HGF, IL10RB, IL12B, 1L18R1, LAP TGF beta 1, MCP3, OSM, TGF alpha, TNFRSF9, TNFS14 and TRANCE; higher levels: CCL11, CCL25, CST5, DNER, LIFR and OPG). Although more than half of these differences (N=15) were present in the comparison between AN and AN-REC, no significant differences were seen between AN-REC and controls. Furthermore, twenty-five proteins correlated positively with BMI (ADA, AXIN1, CASP8, CD5, CD40, CSF1, CXCL1, CXCL5, EN-RAGE, HGF, IL6, IL10RB, IL12B, IL18, IL18R1, LAP TGF beta 1, OSM, SIRT2, STAMBP, TGF alpha, TNFRSF9, TNFS14, TRANCE, TRAIL and VEGFA) and four proteins correlated negatively with BMI (CCL11, CCL25, CCL28 and DNER).These results suggest that a dysregulated inflammatory status is associated with AN, but, importantly, seem to be confined to the acute illness state.