Treatment related psychological distress during adjuvant chemotherapy as a conditioned response.
Treatment related psychological distress during adjuvant chemotherapy as a conditioned response.
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辅助化疗期间治疗相关的心理困扰作为条件反应。
DOI：
10.1093/oxfordjournals.annonc.a058214
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Redd,WH
中科院分区：
文献类型：
--
作者：
Sabbioni,ME;Bovbjerg,DH;Jacobsen,PB;Manne,SL;Redd,WH
接受癌症细胞毒性化疗周期的患者在治疗后经常经历有害的副作用，并且可能在重复输注过程中产生经典的条件性副作用，例如预期性恶心和呕吐（ANV）。本研究探讨了经典条件反射过程也可能导致治疗相关的心理困扰的可能性。66例计划接受乳腺癌（I、II、IIIa期）辅助化疗的患者同意参加研究。患者在每个化疗周期的第一天在诊所进行评估，并在最后一个周期前三到五天在家中进行评估。患者在化疗过程中经历了相当大的心理痛苦，特别是在第一次输注之前。在最后一个化疗周期之前，诊所环境中的心理困扰明显高于患者家中。与经典条件反射一致，心理困扰在治疗前几天并没有升级，而是在患者返回诊所时突然增加。本研究的结果表明，有几个因素参与了患者的预期心理困扰，并强调了条件反射过程可能对患者在临床环境中的情绪困扰做出的潜在贡献。
Patients receiving cycles of cytotoxic chemotherapy for cancer often experience noxious side effects following treatments and may develop classically conditioned side effects, such as anticipatory nausea and vomiting (ANV) during the course of repeated infusions. The present study explored the possibility that classical conditioning processes may also contribute to treatment related psychological distress. Sixty-six patients, scheduled for adjuvant chemotherapy for breast cancer (stages I, II, IIIa), agreed to participate. Patients were assessed in the clinic on the first day of every chemotherapy cycle and in their homes three to five days before their final cycle. Patients experienced considerable psychological distress during the course of chemotherapy, and particularly before the first infusion. Prior to the last cycle of chemotherapy, psychological distress was significantly higher in the clinic environment than in patients' homes. Consistent with classical conditioning, psychological distress did not escalate over the days before treatment, but rather increased abruptly when patients returned to the clinic. The results of the present study indicate that several factors are involved in patients' anticipatory psychological distress and highlight the potential contribution that conditioning processes may make to patients' emotional distress in the clinic environment.