Pancreatic cancer risk and nutrition-related methyl-group availability indicators in male smokers
Pancreatic cancer risk and nutrition-related methyl-group availability indicators in male smokers
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DOI：
10.1093/jnci/91.6.535
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发表时间：
1999-03-17
影响因子：
10.3
通讯作者：
Taylor, PR
中科院分区：
文献类型：
--
作者：
Stolzenberg-Solomon, RZ;Albanes, D;Taylor, PR
背景：胰腺癌的危险因素很少，年龄和吸烟是最一致的。与食用水果和蔬菜相关的保护作用叶酸的主要膳食来源提示影响细胞甲基化反应的因素的作用;然而，据我们所知，没有研究调查这种关系。甲基可用性的生化指标是否与外分泌胰腺癌风险相关是这项调查的重点。研究方法：我们在α-生育酚、β-胡萝卜素癌症预防研究队列中进行了一项巢式病例对照研究，研究对象为29133名50-69岁的芬兰男性吸烟者。将126例外分泌胰腺癌受试者按基线采血日期（+/-30天）、研究中心、年龄（+/-5岁）、试验干预组和完成饮食史与247例对照受试者进行匹配，对照受试者在病例受试者诊断时存活且无癌症。采用条件Logistic回归分析确定优势比（OR）和95%置信区间（CI）。报告的P值是双尾的。结果如下：血清叶酸和吡哆醛-5 '-磷酸（PLP）浓度与胰腺癌风险呈统计学显著的反向剂量反应关系，最高血清三分位数的风险约为最低血清三分位数的一半。（叶酸：OR = 0.45; 95%CI = 0.24-0.82;趋势P = 0.009，PLP：OR = 0.48; 95%CI = 0.26-0.88;趋势P = 0.02）。包年[每天吸烟包数x吸烟年数]，最高与最低四分位数：OR = 2.13; 95% CP = 1.13-3.99;趋势P = 0.04）。结论：这些结果支持了这一假设，即保持足够的叶酸和吡哆醇状态可以降低胰腺癌的风险，并证实了先前与吸烟相关的风险。
Background: Few risk factors for pancreatic cancer have been identified, with age and cigarette smoking being the most consistent. The protective effect associated with consumption of fruits and vegetables-the major dietary sources of folate-is suggestive of a role for factors influencing cellular methylation reactions; however, to our knowledge, no study has investigated this relationship. Whether biochemical indicators of methyl-group availability are associated with exocrine pancreatic cancer risk was the focus of this investigation. Methods: We conducted a nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort of 29133 male Finnish smokers aged 50-69 years. One hundred twenty-six subjects with incident exocrine pancreatic cancer were matched by date of baseline blood draw (+/-30 days), study center, age (+/-5 years), trial intervention group, and completion of dietary history to 247 control subjects, who were alive and free from cancer at the time the case subjects were diagnosed. Odds ratios (ORs) and 95% confidence intervals (CIs) were determined by use of conditional logistic regression. Reported P values are two-tailed. Results: Serum folate and pyridoxal-5'-phosphate (PLP) concentrations showed statistically significant inverse dose-response relationships with pancreatic cancer risk, with the highest serum tertiles having approximately half the risk of the lowest (folate: OR = 0.45; 95% CI = 0.24-0.82; P for trend =.009, and PLP: OR = 0.48; 95% CI = 0.26-0.88; P for trend =.02), An increased pancreatic cancer risk was also observed with greater exposure to cigarettes (e.g., pack-years [number of packs smoked per day x number of years of smoking], highest versus lowest quartile: OR = 2.13; 95% CP = 1.13-3.99; P for trend =.04). Conclusions: These results support the hypothesis that maintaining adequate folate and pyridoxine status may reduce the risk of pancreatic cancer and confirm the risk previously associated with cigarette smoking.