Prolonged neglect following unilateral disruption of a prefrontal cortical-dorsal striatal system
Prolonged neglect following unilateral disruption of a prefrontal cortical-dorsal striatal system
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DOI：
10.1111/j.1460-9568.2005.03892.x
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发表时间：
2005-02-01
影响因子：
3.4
通讯作者：
Everitt, BJ
中科院分区：
文献类型：
--
作者：
Christakou, A;Robbins, TW;Everitt, BJ
我们研究了大鼠内侧前额叶皮质和背内侧纹状体之间的联系形成的系统在注意功能方面的潜在功能。此前已有报道称，切断相同的皮质纹状体回路会导致连续的选择性反应时任务的表现显著下降，同时在自动整形任务中不会获得食欲的巴甫洛夫接近行为(Christakou等人，2001年)。在这里，我们假设同一回路的单侧中断将导致半空间注意力不集中，这与系统完全断开后的全局注意力缺陷形成对比。单侧内侧前额叶皮质(MPFC)和内侧尾壳核(MCPu)的联合损害在同一半球内产生了严重和持久的对侧忽略综合征，同时避免了获得自体成形。这些结果为内侧前额-背内侧纹状体环路参与注意功能提供了进一步的证据，并为深入了解皮质纹状体环路内不同水平损伤后忽视缺陷的性质提供了进一步的证据。
We investigated the potential function of the system formed by connections between the medial prefrontal cortex and the dorsomedial striatum in aspects of attentional function in the rat. It has been reported previously that disconnection of the same corticostriatal circuit produced marked deficits in performance of a serial, choice reaction-time task while sparing the acquisition of an appetitive Pavlovian approach behaviour in an autoshaping task (Christakou et al., 2001). Here, we hypothesized that unilateral disruption of the same circuit would lead to hemispatial inattention, contrasting with the global attention deficit following complete disconnection of the system. Combined unilateral lesions of the medial prefrontal cortex (mPFC) and the medial caudate-putamen (mCPu) within the same hemisphere produced a severe and long-lasting contralesional neglect syndrome while sparing the acquisition of autoshaping. These results provide further evidence for the involvement of the medial prefrontal-dorsomedial striatal circuit in aspects of attentional function, as well as insight into the nature of neglect deficits following lesions at different levels within corticostriatal circuitry.