Acute Liver Failure Secondary to Drug-Induced Liver Injury
Acute Liver Failure Secondary to Drug-Induced Liver Injury
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DOI：
10.1016/j.cld.2019.09.005
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发表时间：
2020-02-01
影响因子：
5.1
通讯作者：
Schiano, Thomas D.
中科院分区：
文献类型：
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作者：
Chayanupatkul, Maneerat;Schiano, Thomas D.
药物性肝损伤（DILI）是西方国家急性肝衰竭（ALF）的最常见原因。如果不进行肝移植，ALF的死亡率接近80%以上。对乙酰氨基酚相关的ALF可能与快速进展有关，但幸运的是，与特异质DILI相关的ALF相比，自发生存的机会很高。已经开发了几种严重DILI的预后评分系统，以帮助临床医生选择需要紧急肝移植的患者。因ALF接受肝移植的患者有早期移植物丢失和死亡的风险，应密切随访。
Drug-induced liver injury (DILI) is the most common cause of acute liver failure (ALF) in Western countries. Without liver transplantation, the mortality rate for ALF approaches greater than 80%. Acetaminophen-related ALF may be associated with a rapid progression but fortunately has a high chance for spontaneous survival compared with idiosyncratic DILI-related ALF. Several prognostic scoring systems for severe DILI have been developed to aid clinicians in selecting patients who require urgent liver transplantation. Patients who undergo liver transplantation for ALF are at risk for early graft loss and death and should be closely followed.