Synchronization, clustering, and weak chimeras in a densely coupled transcription-based oscillator model for split circadian rhythms.
Synchronization, clustering, and weak chimeras in a densely coupled transcription-based oscillator model for split circadian rhythms.
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DOI：
10.1063/5.0156135
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发表时间：
2023-08
期刊：
影响因子：
2.9
通讯作者：
J. L. Ocampo-Espindola;K. L. Nikhil;Jr-Shin Li;E. Herzog;I. Kiss
中科院分区：
文献类型：
--
作者：
J. L. Ocampo-Espindola;K. L. Nikhil;Jr-Shin Li;E. Herzog;I. Kiss
利用转录生物钟基因振荡器模型研究了视交叉上核生物钟基因表达的同步动力学。在恒暗（DD）条件下，该模型表现出单团簇相位同步态，在弱光（dim LL）条件下，表现出单团簇和双团簇的双稳态，在亮光（bright LL）条件下，表现出双团簇态。两簇相位同步状态，其中一些振荡器对同相同步，而一些反相同步，可以解释昼夜节律时钟的分裂，即，某些物种产生两次日常活动，例如，仓鼠。通过将动物从DD或明亮LL转移到昏暗LL，可以达到单簇和双簇状态，即，昼夜节律同步具有记忆效应。通过从常微分方程模型中提取相模型，解析地解释了单团簇和双团簇态的稳定性。在一个具有两个强耦合振子布居且群内耦合较弱的模块网络中，在适当的初始条件下，一个群同步到单群态，另一个群同步到双群态，从而得到弱嵌合态.计算模型表明，睡眠-觉醒的每日节律依赖于作用于视交叉上核（SCN）振荡器双边网络的光强度。添加网络异质性（左右SCN之间的耦合）允许系统表现出嵌合体状态。模拟结果可以指导昼夜节律研究中的实验，以探索光照强度对昼夜节律去同步化复杂性的影响。
The synchronization dynamics for the circadian gene expression in the suprachiasmatic nucleus is investigated using a transcriptional circadian clock gene oscillator model. With global coupling in constant dark (DD) conditions, the model exhibits a one-cluster phase synchronized state, in dim light (dim LL), bistability between one- and two-cluster states and in bright LL, a two-cluster state. The two-cluster phase synchronized state, where some oscillator pairs synchronize in-phase, and some anti-phase, can explain the splitting of the circadian clock, i.e., generation of two bouts of daily activities with certain species, e.g., with hamsters. The one- and two-cluster states can be reached by transferring the animal from DD or bright LL to dim LL, i.e., the circadian synchrony has a memory effect. The stability of the one- and two-cluster states was interpreted analytically by extracting phase models from the ordinary differential equation models. In a modular network with two strongly coupled oscillator populations with weak intragroup coupling, with appropriate initial conditions, one group is synchronized to the one-cluster state and the other group to the two-cluster state, resulting in a weak-chimera state. Computational modeling suggests that the daily rhythms in sleep-wake depend on light intensity acting on bilateral networks of suprachiasmatic nucleus (SCN) oscillators. Addition of a network heterogeneity (coupling between the left and right SCN) allowed the system to exhibit chimera states. The simulations can guide experiments in the circadian rhythm research to explore the effect of light intensity on the complexities of circadian desynchronization.