Expression of Sox1 during Xenopus early embryogenesis
Expression of Sox1 during Xenopus early embryogenesis
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DOI：
10.1016/j.bbrc.2006.10.040
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发表时间：
2006-12-08
影响因子：
3.1
通讯作者：
Asashima, Makoto
中科院分区：
文献类型：
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作者：
Nitta, Kazuhiro R.;Takahashi, Shuji;Asashima, Makoto
Sox B1族基因，即Sox1、Sox2和Sox3（Sox1 - 3），在多种生物的神经发生过程中起作用。在此，我们鉴定了非洲爪蟾的Sox1同源基因，并研究了其表达模式和神经诱导活性。Sox1最初在非洲爪蟾胚胎的前神经板中表达，到尾芽期时其表达局限于脑和视泡。到蝌蚪期时，其在眼部区域的表达随后降低。在动物帽外植体中，Sox1的表达通过抑制骨形态发生蛋白（BMP）信号以与Sox2、Sox3和SoxD相同的方式被诱导。此外，Sox1的过表达在腹侧外胚层和动物帽中诱导了神经标记物。这些结果表明非洲爪蟾的Sox1与神经发生有关，尤其是脑和眼的发育。（c）2006爱思唯尔公司。保留所有权利。
Sox B1 group genes, Sox1, Sox2, and Sox3 (Sox1-3), are involved in neurogenesis in various species. Here, we identified the Xenopus homolog of Sox1, and investigated its expression patterns and neural inducing activity. Sox1 was initially expressed in the anterior neural plate of Xenopus embryos, with expression restricted to the brain and optic vesicle by the tailbud stage. Expression subsequently decreased in the eye region by the tadpole stage. Sox1 expression in animal cap explants was induced by inhibition of BMP signaling in the same manner as Sox2, Sox3, and SoxD. In addition, overexpression of Sox1 induced neural markers in ventral ectoderm and in animal caps. These results implicate Xenopus Sox1 in neurogenesis, especially brain and eye development. (c) 2006 Elsevier Inc. All rights reserved.