Combined therapy with L-Thyroxine and L-Triiodothyronine compared to L-Thyroxine alone in the treatment of primary hypothyroidism
Combined therapy with L-Thyroxine and L-Triiodothyronine compared to L-Thyroxine alone in the treatment of primary hypothyroidism
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DOI：
10.14310/horm.2002.1274
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发表时间：
2010-07-01
影响因子：
3.2
通讯作者：
Dedov, Ivan I.
中科院分区：
文献类型：
--
作者：
Fadeyev, Valentine V.;Morgunova, Tatyana B.;Dedov, Ivan I.
目的：比较L-甲状腺素(L-T4)单用与L-T4与L-三碘甲腺原氨酸(L-T3)联合治疗甲减患者的各项指标。设计：我们对36名患有甲状腺功能减退的绝经前妇女进行了随机对照试验。将患者分为两组：A组(n=20)仅接受L-T4治疗，B组接受L-T4与L-T3联合治疗。疗程6个月。结果：基线时，两组检查的各项参数没有差异。在促甲状腺激素水平、心电监测、密度测量和甲状腺症状评分方面，单一治疗和联合治疗之间没有显著差异。A组治疗期间胆固醇、低密度脂蛋白水平无明显变化，而B组总胆固醇、低密度脂蛋白下降(P<0.05)。
OBJECTIVE: The objective of this study was to compare various parameters in patients with hypothyroidism receiving either monotherapy with L-Thyroxine (L-T4) or combination therapy with L-T4 and L-Triiodothyronine (L-T3). DESIGN: We conducted a randomized, controlled trial in 36 premenopausal women with hypothyroidism. The patients were divided into two groups: Group A (n=20) received only L-T4, while Group B received the combination L-T4 and L-T3. The treatment period lasted for 6 months. RESULTS: At baseline, the various parameters examined did not differ in the two groups. No significant difference between monotherapy and combined therapy was demonstrated on TSH level, ECG monitoring, densitometry, or thyroid symptoms score. The lipid profile was better during combined treatment compared to L-T4 alone; in Group A during treatment with L-T4 the levels of cholesterol and Low Density Lipoprotein (LDL) Cholesterol were unchanged, while in group B total cholesterol and LDL decreased (p