How to approach Alzheimer's disease therapy using stem cell technologies.
How to approach Alzheimer's disease therapy using stem cell technologies.
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DOI：
10.3233/jad-2008-15209
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
K. Sugaya;S. Merchant
中科院分区：
文献类型：
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作者：
K. Sugaya;S. Merchant
使用干细胞进行神经替代疗法不再是科幻小说-这是科学事实。我们已经成功地使用神经和间充质干细胞移植，甚至使用小分子化合物全身注射在大脑中产生神经细胞。我们已经看到，在应用这些干细胞技术后，动物模型的认知功能得到了改善。这些结果可能为基于干细胞的神经替代疗法治疗包括阿尔茨海默病（AD）在内的神经退行性疾病带来光明的前景。然而，在引入临床应用之前，我们必须考虑个体疾病的病理生理环境。我们必须找到可能影响干细胞生物学的病理因素，克服对神经替代的负面影响。在这里，我们不仅讨论了干细胞策略在神经病理条件下的治疗应用潜力，而且还讨论了如何克服由于AD病理条件下改变的因素对干细胞生物学的不利影响。
The use of stem cells for neuroreplacement therapy is no longer science fiction - it is science fact. We have succeeded in producing neural cells in the brain using both neural and mesenchymal stem cell transplantation and even systemic injection using a small molecular compound. We have seen the improvement of cognitive function in animal models following the application of these stem cell technologies. These results may promise a bright future for stem cell based neuroreplacement therapies for neurodegenerative diseases including Alzheimer's disease (AD). However, we have to consider the pathophysiological environments of individual diseases before clinical applications can be introduced. We must find the factors in the pathology that may affect stem cell biology and overcome the negative effects on neuroreplacement. Here, we discuss not only the potential for therapeutic applications of stem cell strategies in neuropathological conditions, but also how to overcome the adverse effects on the biology of stem cells due to the factors that are altered under AD pathology.