Serotonin Syndrome Presenting with Concomitant Tramadol and Diphenhydramine Use: A Case Report of an Unlikely Side-Effect
Serotonin Syndrome Presenting with Concomitant Tramadol and Diphenhydramine Use: A Case Report of an Unlikely Side-Effect
复制标题
DOI：
10.7759/cureus.2421
复制
发表时间：
2018-04-01
影响因子：
1.2
通讯作者：
Norville, Kim J.
中科院分区：
文献类型：
--
作者：
Khan, Salman;Saud, Shakir;Norville, Kim J.
5-羟色胺综合征是在服用5-羟色胺能药物后发生的一种情况。有趣的是，在极少数情况下，它可以发生在各种药物组合中，这些药物可以继而影响血清中5-羟色胺的水平。曲马多是一种止痛剂，具有u阿片受体激动剂活性，也被证明可以抑制5-羟色胺和去甲肾上腺素的再摄取。苯海拉明是第一代组胺拮抗剂，用于治疗或预防过敏反应，也可用作助眠药物。在这里，我们展示了一个5-羟色胺综合征的病例，在使用曲马多治疗颈部疼痛的患者中，服用苯海拉明引起季节性过敏。
Serotonin syndrome is a condition that occurs following the administration of serotonergic drugs. Interestingly, on rare occasions, it can occur with various drug combinations that can secondarily affect the serum levels of 5-hydroxytryptamin. Tramadol is an analgesic that has mu opioid receptor agonist activity and has also been shown to inhibit the reuptake of serotonin and noradrenaline. Diphenhydramine is a first-generation histamine antagonist prescribed to treat or prevent allergic reactions and can also be used as a sleeping aid. Here, we demonstrate a case of serotonin syndrome following the administration of diphenhydramine for seasonal allergies in a patient on tramadol for neck pain.