The DNMT3B-579 G>T promoter polymorphism and risk of lung cancer
The DNMT3B-579 G>T promoter polymorphism and risk of lung cancer
复制标题
DOI：
10.3892/etm.2011.420
复制
发表时间：
2012-03-01
影响因子：
2.7
通讯作者：
Fan, Hong
中科院分区：
文献类型：
--
作者：
Liu, Hui;Jiao, Yifei;Fan, Hong
本研究旨在探讨Dnmt3b启动子-579G>；T多态与肺癌易感性的关系。研究对象为中国北部地区肺癌患者174例，健康对照组135例，性别、年龄匹配。所有受试者均采用聚合酶链式反应-限制性片段长度多态分析进行基因分型，并经DNA测序证实。分层分析用于研究受试者按年龄和性别分组，并评估-579G&gT；T多态与肺癌遗传易感性的关系。结果显示，在研究人群中，携带Dnmt3b-579GT基因的个体患肺癌的风险[优势比(OR)，0.517；95%可信区间(CI)，0.273-0.981]显著低于携带a-579TT基因的个体。但考虑吸烟因素后，GT、GG基因型与肺癌发病风险的差异有统计学意义(OR，0.138，95%CI，0.034~0.549)。本研究的数据表明，Dnmt3b基因多态性在不同种族、民族和地理区域之间存在差异。Dnmt3b-579G>；T基因多态性可能与肺癌的遗传易感性有关。
The present study aimed to investigate the association of the -579 G>T polymorphism in the DNMT3B promoter with susceptibility to lung cancer. A total of 174 lung cancer patients and 135 healthy controls from the northern part of China were enrolled, and were matched for gender and age. All subjects were genotyped by polymerase chain reaction-restriction-fragment length polymorphism analysis and confirmed by DNA sequencing. Stratification analyses were used to study the subgroups of subjects by age and gender, and evaluate the association between the -579 G>T. polymorphism and the genetic susceptibility to lung cancer. The results revealed that individuals with the DNMT3B -579 GT genotype had a significantly decreased risk of lung cancer [odds ratio (OR), 0.517; 95% confidence interval (Cl), 0.273-0.981] compared with those with a -579TT genotype in the studied population. However, the deviation was significant (OR, 0.138, 95% Cl, 0.034-0.549) between the risk of lung cancer and the GT and GG genotype, when the smoking factor was considered. The data from this study indicate that the DNMT3B genetic polymorphism varies among various races, ethnic groups and geographical areas. The DNMT3B -579 G>T polymorphism may contribute to the genetic susceptibility to lung cancer.