Post-operative respiratory rehabilitation after lung resection for non-small cell lung cancer
Post-operative respiratory rehabilitation after lung resection for non-small cell lung cancer
复制标题
DOI：
10.1016/j.lungcan.2007.02.017
复制
发表时间：
2007-08-01
期刊：
影响因子：
5.3
通讯作者：
Granone, Pierluigi
中科院分区：
文献类型：
--
作者：
Cesario, Alfredo;Ferric, Luigi;Granone, Pierluigi
背景：探讨非小细胞肺癌(NSCLC)肺切除术后住院肺康复治疗的疗效。25例患者接受了I-PR，纳入病例组。结果：两组患者的人口学特征、手术特征以及围手术期并发症发生率(对照组为4%，行I-PR组为3%)相似。当比较基线和1个月的数据时，接受治疗的患者的大多数功能参数都得到了改善，尽管多重比较的强大校正限制了Borg分级呼吸困难的统计学意义--中位数-(2比0；p<；0.01)；pH(7.45vs7.42；p<；0.05)；定时步行-6 MWD(297.8 m比393.4 m；p<；0.01)以及6 MWD期间的Hb饱和度(95.4%比93.9%；p<；0.05)。与之相反，对照组术后整体功能均匀质性降低(FEV1和PEF p<；0.01)。两组患者术后1个月的FEV1、FVC、PEF、距离、Hb饱和度和KCO比较，差异无统计学意义，而病例组患者术后4周I-PR治疗后呼吸功能和运动能力明显改善。I-PR可以被认为是接受过LR治疗的癌症患者管理的一个组成部分。(C)2007爱思唯尔爱尔兰有限公司。保留所有权利。
Background: To investigate the efficacy of an inpatient Pulmonary Rehabilitation program (i-PR) after lung resection (LR) for Non-Small Cell Lung Cancer (NSCLC).Patients and methods: From January 2001 to December 2004, 211 out of 618 patients who underwent LR were considered eligible for i-PR. Twenty-five patients accepted the i-PR and were included in the case group. The remaining 186 who refused i-PR were taken as controls.Results: The two study groups were comparable for demographic and surgical characteristics, as well as for the peri-operative morbidity (4% in the controls and 3% among patients undergoing i-PR). Most functional parameters among treated patients were improved when baseline versus 1-month figures were compared, despite the strong correction for multiple comparison limited statistical significance to Borg scale dyspnoea on exertion - median - (2 versus 0; p < 0.01); pH (7.45 versus 7.42; p < 0.05); timed walk-6MWD (297.8 m versus 393.4 m; p < 0.01) and Hb saturation during 6 MWD (95.4% versus 93.9%; p < 0.05). On the contrary, global function in the group of controls was homogeneously decreased (FEV1 and PEF p < 0.01) after operation. The comparison of treated and untreated patients 1 month after the operation did not show any significant difference in terms of FEV1, FVC, PEF, distance, Hb saturation, and KCO that instead were homogeneously and significantly worse at baseline (before the surgical operation) in the case group.Conclusions: Respiratory Function and exercise capacity significantly improve following a postoperative 4-week i-PR in lung resected patients. i-PR could be regarded as a component of the management of patients who have undergone LR for cancer. (C) 2007 Elsevier Ireland Ltd. All rights reserved.