Predictive factors for pneumonia development and progression to respiratory failure in MERS-CoV infected patients.
Predictive factors for pneumonia development and progression to respiratory failure in MERS-CoV infected patients.
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DOI：
10.1016/j.jinf.2016.08.005
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发表时间：
2016-11
期刊：
影响因子：
--
通讯作者：
Peck KR
中科院分区：
文献类型：
--
作者：
Ko JH;Park GE;Lee JY;Lee JY;Cho SY;Ha YE;Kang CI;Kang JM;Kim YJ;Huh HJ;Ki CS;Jeong BH;Park J;Chung CR;Chung DR;Song JH;Peck KR
2015年韩国中东呼吸综合征(MERS)暴发后，在控制MERS疫情时，强调了对肺炎发展和进展为呼吸衰竭的预测。对2015年韩国MERS疫情期间在三级护理中心接受治疗的MERS冠状病毒感染者进行了回顾。为了分析肺炎发展和进展为呼吸衰竭的预测因素，我们评估了症状出现后三天内测量的临床变量。共有45名患者纳入研究：13名患者(28.9%)没有发展为肺炎，19名患者发展为肺炎但无呼吸衰竭(42.2%)，13名患者进展为呼吸衰竭(28.9%)。已确定的肺炎发生的预测因素包括年龄≥45岁，发热≥37.5℃，血小板减少，淋巴细胞减少，C反应蛋白≥2 mg/dL，以及PCR值小于28.5。对于呼吸衰竭，指标包括男性、高血压、低白蛋白浓度、血小板减少、淋巴细胞减少和C反应蛋白≥4 mg/dL(均P<0.05)。≥是肺炎发生的两个预测因子，100%的患者发生肺炎。缺乏预测因素的患者不会进展为呼吸衰竭。为成功控制MERS暴发，对感染≥两个预测因素的患者，应从最初的表现开始就加强管理。对MERS患者肺炎进展的预测因素进行了研究。临床变量是在症状出现后三天内测量的。发现了肺炎和呼吸衰竭的6个预测因素。≥是肺炎的两个预测因子，100%的患者发生肺炎。缺乏预测因素的患者不会进展为呼吸衰竭。
After the 2015 Middle East respiratory syndrome (MERS) outbreak in Korea, prediction of pneumonia development and progression to respiratory failure was emphasized in control of MERS outbreak. MERS-CoV infected patients who were managed in a tertiary care center during the 2015 Korean MERS outbreak were reviewed. To analyze predictive factors for pneumonia development and progression to respiratory failure, we evaluated clinical variables measured within three days from symptom onset. A total of 45 patients were included in the study: 13 patients (28.9%) did not develop pneumonia, 19 developed pneumonia without respiratory failure (42.2%), and 13 progressed to respiratory failures (28.9%). The identified predictive factors for pneumonia development included age ≥45 years, fever ≥37.5 °C, thrombocytopenia, lymphopenia, CRP ≥ 2 mg/dL, and a threshold cycle value of PCR less than 28.5. For respiratory failure, the indicators included male, hypertension, low albumin concentration, thrombocytopenia, lymphopenia, and CRP ≥ 4 mg/dL (all P < 0.05). With ≥ two predictive factors for pneumonia development, 100% of patients developed pneumonia. Patients lacking the predictive factors did not progress to respiratory failure. For successful control of MERS outbreak, MERS-CoV infected patients with ≥ two predictive factors should be intensively managed from the initial presentation. Predictive factors for pneumonia progression in MERS patients were investigated. Clinical variables measured within three days from symptom onset were used. Six predictive factors for pneumonia development and respiratory failure were found. With ≥ two predictive factors for pneumonia, 100% of patients developed pneumonia. Patients lacking the predictive factors did not progress to respiratory failure.
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DOI：
10.1016/s0140-6736(13)60982-4
发表时间：
2013-06-29
期刊：
Lancet (London, England)
影响因子：
--
作者：
Guery B;Poissy J;el Mansouf L;Séjourné C;Ettahar N;Lemaire X;Vuotto F;Goffard A;Behillil S;Enouf V;Caro V;Mailles A;Che D;Manuguerra JC;Mathieu D;Fontanet A;van der Werf S;MERS-CoV study group
通讯作者：
MERS-CoV study group
DOI：
10.1164/rccm.201406-1031oc
发表时间：
2015-04-01
影响因子：
24.7
作者：
Vuong Ba Le;Schneider, Jochen G.;Riteau, Beatrice
通讯作者：
Riteau, Beatrice
影响因子：
4.6
作者：
Min CK;Cheon S;Ha NY;Sohn KM;Kim Y;Aigerim A;Shin HM;Choi JY;Inn KS;Kim JH;Moon JY;Choi MS;Cho NH;Kim YS
通讯作者：
Kim YS
影响因子：
11.8
作者：
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影响因子：
11.8
作者：
Majumder, Maimuna S.;Kluberg, Sheryl A.;Brownstein, John S.
通讯作者：
Brownstein, John S.