Intestinal microflora and gastrointestinal adaptation in the rat in response to non-digestible dietary polysaccharides
Intestinal microflora and gastrointestinal adaptation in the rat in response to non-digestible dietary polysaccharides
复制标题
大鼠肠道微生物区系和胃肠道适应对不可消化膳食多糖的反应
DOI：
10.1079/bjn19880091
复制
发表时间：
1988
影响因子：
3.6
通讯作者：
I. Johnson
中科院分区：
文献类型：
--
作者：
G. Wyatt;N. Horn;J. Gee;I. Johnson
1.比较了无纤维饮食和含有不可消化多糖的饮食对大鼠盲肠和结肠生理学和微生物区系的影响。2.所有含多糖的饮食导致盲肠和结肠的扩大，与内容物和组织的重量增加有关。羧甲基纤维素（CMC）具有最显著的效果，给予该物质的动物也有水样粪便。3.盲肠和结肠中的细菌密度随饲料变化显着，CMC饲料增加了植物群中需氧菌的比例。4.在体外，CMC和羟丙基甲基纤维素发酵不良。5.组织重量与器官内容物湿重之间存在高度相关性（盲肠r 0.93;结肠r 0.94），但与细菌密度、每个器官的细菌数量、含水量或短链脂肪酸含量无关。6.它的结论是盲肠和结肠扩大是由于组织肥大的内容物体积的增加，无论该散装随饮食而变化的性质;它是不可能的，短链脂肪酸或其他微生物代谢产物的刺激物的营养反应时看到的不可消化的膳食多糖喂给大鼠。
1. A comparison was made of the effect of a fibre-free diet and diets containing non-digestible polysaccharides on rat caecal and colonic physiology and microflora. 2. All polysaccharide-containing diets led to enlargement of the caecum and colon, associated with increased weight of contents, and of tissue. Carboxymethylcellulose (CMC) had the most marked effect and animals given this also had watery faeces. 3. The density of bacteria in the caecum and colon varied significantly with diet and the proportion of aerobic bacteria in the flora was increased by the CMC diet. 4. In vitro, CMC and hydroxypropylmethylcellulose were poorly fermented. 5. There was a high correlation (caecum r 0.93; colon r 0.94) between tissue weight and wet weight of organ contents but no correlation with bacterial density, number of bacteria per organ, moisture content or short-chain fatty acid content. 6. It is concluded that caecal and colonic enlargement is due to tissue hypertrophy in response to increased bulk of contents, irrespective of the nature of that bulk which varies with diet; it is unlikely that short-chain fatty acids or other microbial metabolites are the stimulus for the trophic response seen when non-digestible dietary polysaccharides are fed to rats.